Maruyama Takahiro, Shiba Tomoaki, Kobayashi Tatsuhiko, Takagi Seiji, Hori Yuichi
Department of Ophthalmology, Tokyo Shinagawa Hospital, Tokyo 140-8522, Japan.
Department of Ophthalmology, Toho University Graduate School of Medicine, Tokyo 143-8541, Japan.
Diagnostics (Basel). 2025 Aug 12;15(16):2021. doi: 10.3390/diagnostics15162021.
This study aims to investigate ocular blood flow in male subjects with metabolic syndrome (MetS) using laser speckle flowgraphy (LSFG). Subjects who underwent LSFG ocular blood flow testing during physical examinations were separated into a MetS group and a control group. The groups were propensity score-matched by age, with 138 male subjects compared in each group. The subjects' ocular blood flow (mean blur rate, MBR) in the optic nerve head (ONH) and choroid was measured via LSFG. Pulse waveform parameters, the blowout score (BOS), blowout time (BOT), and rising rate (RR), were also measured. The ONH region was measured as a whole and as tissue and vascular regions. The MBR-Choroid was significantly lower in the MetS group versus the control group. There was no significant difference in the MBR in the ONH. Compared to the control group, the RR values in the MetS group were significantly lower in all regions. The whole tissue region and vascular region BOS values were significantly higher in the MetS group. A single-regression analysis revealed that among the evaluated parameters, only the number of MetS components was significantly negatively correlated with the MBR-Choroid. A multiple regression analysis identified HbA1c as a factor contributing independently to the MBR-Choroid among the MetS-related factors. This investigation of adult males clarified that in the early stage of MetS, the MBR in the choroid area decreases in parallel with the accumulation of MetS components. The MetS component with the strongest influence on the MBR-Choroid was HbA1c.
本研究旨在使用激光散斑血流图（LSFG）研究患有代谢综合征（MetS）的男性受试者的眼部血流情况。在体检期间接受LSFG眼部血流测试的受试者被分为MetS组和对照组。两组按年龄进行倾向得分匹配，每组比较138名男性受试者。通过LSFG测量受试者视神经乳头（ONH）和脉络膜的眼部血流（平均模糊率，MBR）。还测量了脉搏波形参数、扩张分数（BOS）、扩张时间（BOT）和上升速率（RR）。对ONH区域作为一个整体以及作为组织和血管区域进行了测量。与对照组相比，MetS组的脉络膜MBR显著更低。ONH的MBR没有显著差异。与对照组相比，MetS组所有区域的RR值均显著更低。MetS组的整个组织区域和血管区域的BOS值显著更高。单因素回归分析显示，在评估参数中，只有MetS组分数量与脉络膜MBR显著负相关。多因素回归分析确定糖化血红蛋白（HbA1c）是MetS相关因素中独立影响脉络膜MBR的一个因素。这项对成年男性的调查表明，在MetS早期，脉络膜区域的MBR随着MetS组分的积累而平行下降。对脉络膜MBR影响最强的MetS组分是HbA1c。
