Bonasoni Maria Paola, Zuntini Roberta, Shah Khush, De Marco Loredana, Zanetti Eleonora, Pagliai Luca, Blasi Immacolata, Carossino Emanuela, Ferretti Alice, Mandato Vincenzo Dario, Aguzzoli Lorenzo
Pathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy.
Clinical Genetics Unit, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy.
Diagnostics (Basel). 2025 Aug 13;15(16):2024. doi: 10.3390/diagnostics15162024.
: Ovarian ectopic pregnancy (OEP) is a rare occurrence, and molar degeneration is even more exceptional. Differential diagnosis between a partial and complete hydatidiform mole is paramount as the complete type carries a higher risk of post-molar gestational trophoblastic neoplasia. Herein, we describe a case of a partial mole in an OEP (OPHM) with thorough investigations. : A 39-year-old woman presented at 6 weeks of amenorrhea with abdominal pain and vaginal bleeding. Ultrasound showed no intrauterine pregnancy, but an ovarian cyst suspicious for OEP. The patient underwent surgical removal of the cyst. Histological diagnosis was suspicious for OPHM with only one abnormal villous. Immunohistochemistry for p57 and fluorescent in situ hybridization (FISH) were not conclusive. STR-based (Short Tandem Repeat) molecular technique demonstrated the chromosomal asset of 69,XXX, confirming the diagnosis of OPHM. The patient was fully monitored for 1 year with periodic measurements of beta-hCG levels. After that period, the patient was in good health and disease-free. : Histologically, ancillary techniques might not be sufficient to confirm the diagnosis of a hydatidiform mole, especially if the tissue available is scarce. In this case, STR has been demonstrated an effective tool in defining the chromosomal asset, even in paraffin-embedded samples.
卵巢异位妊娠（OEP）较为罕见，而葡萄胎样变性则更为罕见。部分性葡萄胎和完全性葡萄胎的鉴别诊断至关重要，因为完全性葡萄胎发生葡萄胎后妊娠滋养细胞肿瘤的风险更高。在此，我们详细描述了一例卵巢异位妊娠合并部分性葡萄胎（OPHM）的病例。一名39岁女性在停经6周时出现腹痛和阴道出血。超声检查显示宫内未见妊娠，但有一个可疑为卵巢异位妊娠的卵巢囊肿。患者接受了囊肿切除术。组织学诊断怀疑为OPHM，仅见一个异常绒毛。p57免疫组化和荧光原位杂交（FISH）结果不明确。基于短串联重复序列（STR）的分子技术显示染色体组成为69,XXX，确诊为OPHM。对患者进行了为期1年的全面监测，定期检测β - hCG水平。此后，患者身体健康，无疾病。组织学上，辅助技术可能不足以确诊葡萄胎，尤其是在可用组织稀少的情况下。在本病例中，STR已被证明是确定染色体组成的有效工具，即使在石蜡包埋样本中也是如此。
