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用于诊疗的叶酸修饰白蛋白功能化氧化铁纳米颗粒：工程化及乳腺癌细胞系的体外光动力疗法治疗

Folate-Modified Albumin-Functionalized Iron Oxide Nanoparticles for Theranostics: Engineering and In Vitro PDT Treatment of Breast Cancer Cell Lines.

作者信息

Bychkova Anna V, Gorobets Maria G, Toroptseva Anna V, Markova Alina A, Nguyen Minh Tuan, Volodina Yulia L, Gradova Margarita A, Abdullina Madina I, Mayorova Oksana A, Kasparov Valery V, Pokrovsky Vadim S, Kolotaev Anton V, Khachatryan Derenik S

机构信息

Emanuel Institute of Biochemical Physics of Russian Academy of Sciences, 4, Kosygina Str., Moscow 119334, Russia.

N.N. Blokhin National Medical Research Center of Oncology, 24, Kashirskoye Sh., Moscow 115478, Russia.

出版信息

Pharmaceutics. 2025 Jul 30;17(8):982. doi: 10.3390/pharmaceutics17080982.

DOI:10.3390/pharmaceutics17080982
PMID:40871005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12389551/
Abstract

: Magnetic iron oxide nanoparticles (IONPs), human serum albumin (HSA) and folic acid (FA) are prospective components for hybrid nanosystems for various biomedical applications. The magnetic nanosystems FA-HSA@IONPs (FAMs) containing IONPs, HSA, and FA residue are engineered in the study. : Composition, stability and integrity of the coating, and peroxidase-like activity of FAMs are characterized using UV/Vis spectrophotometry (colorimetric test using o-phenylenediamine (OPD), Bradford protein assay, etc.), spectrofluorimetry, dynamic light scattering (DLS) and electron magnetic resonance (EMR). The selectivity of the FAMs accumulation in cancer cells is analyzed using flow cytometry and confocal laser scanning microscopy. : FAMs (d~55 nm by DLS) as a drug delivery platform have been administered to cancer cells (human breast adenocarcinoma MCF-7 and MDA-MB-231 cell lines) in vitro. Methylene blue, as a model photosensitizer, has been non-covalently bound to FAMs. An increase in photoinduced cytotoxicity has been found upon excitation of the photosensitizer bound to the coating of FAMs compared to the single photosensitizer at equivalent concentrations. The suitability of the nanosystems for photodynamic therapy has been confirmed. : FAMs are able to effectively enter cells with increased folate receptor expression and thus allow antitumor photosensitizers to be delivered to cells without any loss of their in vitro photodynamic efficiency. Therapeutic and diagnostic applications of FAMs in oncology are discussed.

摘要

磁性氧化铁纳米颗粒（IONPs）、人血清白蛋白（HSA）和叶酸（FA）是用于各种生物医学应用的混合纳米系统的潜在成分。本研究构建了包含IONPs、HSA和FA残基的磁性纳米系统FA-HSA@IONPs（FAMs）。使用紫外/可见分光光度法（邻苯二胺（OPD）比色试验、Bradford蛋白测定等）、荧光分光光度法、动态光散射（DLS）和电子磁共振（EMR）对FAMs的组成、包衣的稳定性和完整性以及过氧化物酶样活性进行了表征。使用流式细胞术和共聚焦激光扫描显微镜分析了FAMs在癌细胞中积累的选择性。作为药物递送平台的FAMs（通过DLS测得直径约为55nm）已在体外应用于癌细胞（人乳腺腺癌MCF-7和MDA-MB-231细胞系）。亚甲蓝作为模型光敏剂，已非共价结合到FAMs上。与同等浓度的单一光敏剂相比，发现与FAMs包衣结合的光敏剂受激发后光诱导细胞毒性增加。已证实该纳米系统适用于光动力疗法。FAMs能够有效进入叶酸受体表达增加的细胞，从而使抗肿瘤光敏剂能够递送至细胞，而不会损失其体外光动力效率。讨论了FAMs在肿瘤学中的治疗和诊断应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c1/12389551/d0520d087dae/pharmaceutics-17-00982-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c1/12389551/990ca868120f/pharmaceutics-17-00982-sch001.jpg
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