Phan Anna, Mijar Sanjaya, Harvey Catherine, Biswas Debabrata
Biological Sciences Program-Molecular and Cellular Biology, University of Maryland, College Park, MD 20742, USA.
Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA.
Microorganisms. 2025 Jul 24;13(8):1732. doi: 10.3390/microorganisms13081732.
Foodborne diseases are the most common causes of illness worldwide. Bacterial pathogens, including , are often involved in foodborne disease and pose a serious threat to human health. is commonly found in humans and a variety of animal species. Staphylococcal enteric disease, specifically staphylococcal food poisoning (SFP), accounts for numerous gastrointestinal illnesses, through the contamination of food with its enterotoxins, and its major impact on human health imposes a heavy economic burden in society. Commonly, antibiotics and antimicrobials are used to treat SFP. However, a range of complications may arise with these treatments, impeding the control of diseases specifically caused by methicillin-resistant (MRSA). Natural alternative options to control diseases, such as bacteriophages, plant-based antimicrobials, nanoparticle-based or light-based therapeutics, and probiotics, are promising in terms of overcoming these existing problems as they are environmentally friendly, abundant, unlikely to induce resistance in pathogens, cost-effective, and safe for human health. Recent findings have indicated that these alternatives may reduce the colonization and infection of major foodborne pathogens, including MRSA, which is crucial to overcome the spread of antibiotic resistance in . This review focuses on the present scenario of in foodborne disease, its economic importance and current interventions and, most importantly, the implications of natural antimicrobials, especially probiotics and synbiotics, as alternative antimicrobial means to combat pathogenic microorganisms particularly, and MRSA.
食源性疾病是全球最常见的致病原因。包括……在内的细菌病原体经常引发食源性疾病，对人类健康构成严重威胁。……常见于人类和多种动物物种中。葡萄球菌肠道疾病，特别是葡萄球菌食物中毒（SFP），通过食物被其肠毒素污染导致众多胃肠道疾病，其对人类健康的重大影响给社会带来了沉重的经济负担。通常，抗生素和抗菌药物用于治疗SFP。然而，这些治疗可能会引发一系列并发症，阻碍对由耐甲氧西林……（MRSA）引起的疾病的控制。控制……疾病的天然替代方案，如噬菌体、植物源抗菌剂、纳米颗粒或光基疗法以及益生菌，在克服这些现有问题方面很有前景，因为它们环保、丰富、不太可能诱导病原体产生耐药性、具有成本效益且对人类健康安全。最近的研究结果表明，这些替代方案可能会减少包括MRSA在内的主要食源性病原体的定植和感染，这对于克服……中抗生素耐药性的传播至关重要。本综述重点关注……在食源性疾病中的现状、其经济重要性和当前的干预措施，最重要的是，天然抗菌剂，特别是益生菌和合生元作为对抗致病微生物特别是……和MRSA的替代抗菌手段的意义。
