Piątek-Gołda Wiktoria, Osińska-Jaroszuk Monika, Pawlik Anna, Komoń-Janczara Elwira, Sulej Justyna
Department of Biochemistry and Biotechnology, Institute of Biological Sciences, Maria Curie-Sklodowska University, 19 Akademicka St., 20-033 Lublin, Poland.
Department of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, 8 Skromna St., 20-704 Lublin, Poland.
Molecules. 2025 Aug 9;30(16):3330. doi: 10.3390/molecules30163330.
Lactobionic acid, widely used in the pharmaceutical, cosmetic, and food industries, is produced through chemical and biological methods, each with distinct advantages and challenges. This review examines the key approaches to its production, highlighting the chemical oxidation of lactose and biotechnological processes using microbial and enzymatic systems. Chemical methods offer high yields and rapid production but are often hindered by environmental concerns and lower product purity. In contrast, biological methods provide eco-friendly alternatives with superior product quality, albeit with limitations in scalability and higher initial costs. The comparison in this overview focuses on productivity, cost efficiency, purity, and environmental impacts, underscoring the potential of biological methods to align with sustainability goals. This review highlights further advances in biological approaches and explores hybrid solutions that combine the strengths of both methods for optimal lactobionic acid production.
乳糖酸广泛应用于制药、化妆品和食品工业，可通过化学和生物方法生产，每种方法都有其独特的优点和挑战。本综述探讨了其生产的关键方法，重点介绍了乳糖的化学氧化以及使用微生物和酶系统的生物技术过程。化学方法产量高、生产速度快，但往往受到环境问题和产品纯度较低的阻碍。相比之下，生物方法提供了具有卓越产品质量的环保替代方案，尽管在可扩展性方面存在局限性且初始成本较高。本综述中的比较侧重于生产率、成本效益、纯度和环境影响，强调了生物方法符合可持续发展目标的潜力。本综述突出了生物方法的进一步进展，并探索了结合两种方法的优势以实现乳糖酸最佳生产的混合解决方案。
