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线性及某些非线性药物处置的模型无关消除/分布函数分解的定理及推论。II. 应用于分布动力学评估的清除概念。

Theorems and implications of a model-independent elimination/distribution function decomposition of linear and some nonlinear drug dispositions. II. Clearance concepts applied to the evaluation of distribution kinetics.

作者信息

Gillespie W R, Veng-Pedersen P

出版信息

J Pharmacokinet Biopharm. 1985 Aug;13(4):441-51. doi: 10.1007/BF01061479.

DOI:10.1007/BF01061479
PMID:4087171
Abstract

The disposition decomposition approach is employed to derive clearance parameters descriptive of drug distribution kinetics. The name distribution clearance, CLd, is given to a characteristic constant of linear and some nonlinear pharmacokinetic systems. CLd is the clearance associated with the steady-state rate of drug transfer from the peripheral tissues to the systemic circulation. Also introduced is the elimination clearance, CLe, which is associated with the total drug transfer rate from the systemic circulation in linear systems. Estimates of CLd and CLe are presented for several drugs.

摘要

采用处置分解方法来推导描述药物分布动力学的清除率参数。线性和一些非线性药代动力学系统的一个特征常数被命名为分布清除率（CLd）。CLd是与药物从外周组织向体循环的稳态转运速率相关的清除率。还引入了消除清除率（CLe），它与线性系统中药物从体循环的总转运速率相关。给出了几种药物的CLd和CLe估计值。

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本文引用的文献

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A physiological and system analysis hybrid pharmacokinetic model to characterize carbon tetrachloride blood concentrations following administration in different oral vehicles.一种用于表征不同口服载体给药后四氯化碳血药浓度的生理与系统分析混合药代动力学模型。
J Pharmacokinet Biopharm. 1993 Oct;21(5):551-74. doi: 10.1007/BF01059114.
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A technique for calculating the mean time for equilibration of drug distribution using minimal structural assumptions.一种使用最少结构假设来计算药物分布平衡平均时间的技术。
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Variability in derived parameters of furosemide pharmacokinetics.呋塞米药代动力学衍生参数的变异性。
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Pharmacokinetics of intravenous chloramphenicol sodium succinate in adult patients with normal renal and hepatic function.静脉注射琥珀氯霉素钠在肾功能和肝功能正常的成年患者中的药代动力学。
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