胶束对吲哚美辛及相关化合物碱性水解的影响。

Micellar effects on the basic hydrolysis of indomethacin and related compounds.

作者信息

Cipiciani A, Ebert C, Germani R, Linda P, Lovrecich M, Rubessa F, Savelli G

出版信息

J Pharm Sci. 1985 Nov;74(11):1184-7. doi: 10.1002/jps.2600741110.

Abstract

The kinetics of hydrolysis of indomethacin and related compounds was studied in an alkaline medium at 25 degrees C in the presence of anionic (sodium dodecyl sulfate) and cationic (hexadecyltrimethylammonium bromide) surfactants. The rate-surfactant profiles for rate inhibition in the presence of sodium dodecyl sulfate and rate enhancement in the presence of hexadecyltrimethylammonium bromide were analyzed in terms of the current theory of micellar effects.

摘要

在25摄氏度的碱性介质中，于阴离子（十二烷基硫酸钠）和阳离子（十六烷基三甲基溴化铵）表面活性剂存在的情况下，研究了吲哚美辛及相关化合物的水解动力学。根据当前的胶束效应理论，分析了在十二烷基硫酸钠存在下速率抑制以及在十六烷基三甲基溴化铵存在下速率增强的速率-表面活性剂曲线。