嘌呤无环核苷。6-二甲基氨基-9-[(2-苯丙氨酰胺基-1-取代-乙氧基)甲基]嘌呤作为候选抗病毒药物。
Purine acyclic nucleosides. 6-Dimethylamino-9-[(2-phenylalanylamido-1-substituted- ethoxy)methyl]purines as candidate antivirals.
作者信息
Kelley J L, Selway J W, Schaeffer H J
出版信息
J Pharm Sci. 1985 Dec;74(12):1302-4. doi: 10.1002/jps.2600741211.
PMID:4087197
Abstract
Several acyclic puromycin analogues containing hydrocarbon substituents on the 1'-position of the aminoethoxymethyl moiety were synthesized and tested for antiviral activity. The N-carbobenzoxy intermediate 7c was active in vitro against Mengo and Semliki Forest viruses.
摘要
合成了几种在氨基乙氧基甲基部分的1'-位含有烃取代基的无环嘌呤霉素类似物，并测试了它们的抗病毒活性。N-苄氧羰基中间体7c在体外对门戈病毒和塞姆利基森林病毒具有活性。
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