Kwak Eun Yee, Hong Joon Hee, Park Youngja, Choi Bo Gil
College of Pharmacy, Chonnam National University, Kwangju 500-757, Korea.
Arch Pharm Res. 2003 Sep;26(9):679-85. doi: 10.1007/BF02976674.
A series of novel cyclopropyl nucleosides was synthesized using the highly stereoselective Simmons-Smith reaction starting from 1,2:5,6-di-O-isopropylidene-D-mannitol. The structural assignments of these nucleosides were determined by NMR studies and X-ray crystallography. All the synthesized nucleosides were assayed against several viruses.
以1,2:5,6-二-O-异亚丙基-D-甘露醇为起始原料，通过高度立体选择性的西蒙斯-史密斯反应合成了一系列新型环丙基核苷。通过核磁共振研究和X射线晶体学确定了这些核苷的结构归属。对所有合成的核苷进行了几种病毒的检测。
