Smejkal V, Palecek F, Frydrychova M
J Physiol (Paris). 1985;80(3):173-6.
The intensity of the Breuer-Hering inflation reflex was studied in newborn (1 day old), in young (8 days old) and in adult rats (90 days old) under urethane general anaesthesia (1.3 g/kg i.p.). The inflation pressure was adjusted with the aid of a water-valve. The reflex was present in all 3 age groups. An inflation pressure of 0.2 kPa applied in the course of expiration produced a long lasting apnoea in newborn rats which lasted 48 normal respiratory cycles. An inflation pressure of 0.5 kPa in young rats induced an apnoea lasting for only 3 normal respiratory cycles, whereas a pressure of 1 kPa in adult rats led to an apnoea which lasted for 20 normal respiratory cycles. The compliance of the respiratory system in relation to lung weight is approximately 5 times higher in adult rats compared with that of newborn rats. It is approximately double in comparison with young rats. The pressures of inflation mentioned in the 3 age categories can be considered as equieffective from the point of stimulation pulmonary stretch receptors. It can be concluded from these findings that the reflex of Breuer-Hering in newborn rats is more potent in comparison with adult rats, but it is lower in young rats at the age of 8 days. It is suggested that the differences observed are due to functional and anatomical maturation.
在氨基甲酸乙酯全身麻醉（腹腔注射1.3 g/kg）下，研究了新生大鼠（1日龄）、幼鼠（8日龄）和成年大鼠（90日龄）的布瑞尔-黑林充气反射强度。借助水阀调节充气压力。所有3个年龄组均存在该反射。在呼气过程中施加0.2 kPa的充气压力会使新生大鼠产生持续较长时间的呼吸暂停，持续48个正常呼吸周期。0.5 kPa的充气压力在幼鼠中诱发的呼吸暂停仅持续3个正常呼吸周期，而1 kPa的压力在成年大鼠中导致的呼吸暂停持续20个正常呼吸周期。与新生大鼠相比，成年大鼠呼吸系统相对于肺重量的顺应性大约高5倍。与幼鼠相比大约是两倍。从刺激肺牵张感受器的角度来看，上述3个年龄组的充气压力可被视为等效。从这些发现可以得出结论，与成年大鼠相比，新生大鼠的布瑞尔-黑林反射更强，但在8日龄的幼鼠中则较弱。提示观察到的差异是由于功能和解剖学成熟所致。
