Hanácek J, Korpás J
Physiol Bohemoslov. 1982;31(2):169-74.
Too little is known of the mechanisms participating in the regulation of defence reflexes of the organs of respiration. The activity of respiratory tract--in particular lung stretch and cough receptors--may play an important role. In the present study the authors investigated the effect of short-term inflation of the lungs, during which lung stretch receptors are mainly stimulated, on the expiration reflex, which is one of the respiratory defence reflexes. The experiments were carried out on 18 rabbits (2.5-2.8 kg) under general anaesthesia (Pentobarbital Spofa, 30 mg.kg-1 i.v.). The VT, V', Ppl and systemic BP were recorded. The expiration reflex was elicited by stimulating the vocal folds with a silon fibre loop during resting respiration and during inflation of the lungs with pressures of 0.49, 0.98 and 1.47 kPa. The criterion of the intensity of the expiration reflex was the Ppl expressed in kPa. The authors found that the intensity of the expiration reflex during resting respiration was 0.29 +/- 0.02 kPa (S.E.M.). An inflation pressure of 0.49 kPa raised it to 0.69 +/- 0.06 kPa, a pressure of 0.98 kPa raised it still further to 1.12 +/- 0.06 kPa and a pressure of 1.47 kPa raised it yet again to 1.59 +/- 0.08 kPa. In the authors' opinion, the increase in the intensity of the reflex is due to augmented activity of lung stretch receptors.
目前对于参与呼吸器官防御反射调节的机制了解甚少。呼吸道的活动——尤其是肺牵张和咳嗽感受器——可能起着重要作用。在本研究中，作者研究了主要刺激肺牵张感受器的肺短期充气对呼气反射（呼吸防御反射之一）的影响。实验在18只体重2.5 - 2.8千克的兔子身上进行，采用戊巴比妥钠（30毫克/千克静脉注射）全身麻醉。记录潮气量（VT）、分钟通气量（V'）、胸膜腔内压（Ppl）和体循环血压。在静息呼吸期间以及用0.49、0.98和1.47千帕的压力使肺充气期间，用硅酮纤维环刺激声带诱发呼气反射。呼气反射强度的标准是用千帕表示的胸膜腔内压。作者发现静息呼吸期间呼气反射的强度为0.29±0.02千帕（标准误）。0.49千帕的充气压力使其升至0.69±0.06千帕，0.98千帕的压力使其进一步升至1.12±0.06千帕，1.47千帕的压力使其再次升至1.59±0.08千帕。作者认为，反射强度的增加是由于肺牵张感受器活动增强所致。
