Bagga Ruchika, Fuller Charlotte, Shahzad Kalsoom, Bado Ezra, Joshi Judith, Fernando Dileesha, Hempel Amanda, Boggild Andrea K
Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada.
Department of Pathobiology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada.
Pathogens. 2025 Aug 3;14(8):768. doi: 10.3390/pathogens14080768.
Given the overlap of epidemiological and clinical presentations of both rickettsioses and malaria infections, diagnostic testing where malaria is confirmed or excluded, without subsequent rickettsial testing, specifically in the case of or infection, may mask the possibility of relapse. A lack of clinical suspicion of co-infections, absence of knowledge on the geographic distribution of diseases, and lack of availability of point-of-care diagnostic testing for other tropical diseases can often lead to missed diagnosis or misdiagnosis of common tropical infections, including rickettsioses. We herein describe a case of confirmed intercurrent rickettsial and infection, with the former potentially triggering a relapse of the latter in a febrile traveler returning to Canada from South America, and review the literature on tropical coinfections in returning travelers.
鉴于立克次体病和疟疾感染在流行病学和临床表现上存在重叠，在确诊或排除疟疾后却未进行后续立克次体检测的诊断性检测，特别是在[此处原文可能缺失具体疾病名称]感染的情况下，可能会掩盖复发的可能性。对合并感染缺乏临床怀疑、对疾病地理分布缺乏了解以及缺乏针对其他热带疾病的即时诊断检测，常常会导致对包括立克次体病在内的常见热带感染漏诊或误诊。我们在此描述一例确诊的立克次体病与[此处原文可能缺失具体疾病名称]并发感染的病例，在一名从南美洲返回加拿大的发热旅行者中，前者可能引发了后者的复发，并回顾了有关归国旅行者中热带合并感染的文献。
