Soriano Isabel García, Romero Mónica, Gascón Isabel, Solves Verónica, Pascual Reyes, Wikman-Jorgensen Philip Erick
Infectious Diseases Unit, Department of Internal Medicine, Hospital General Universitario de Elda-FISABIO, 03600 Elda, Spain.
Department of Clinical Medicine, Miguel Hernández University, 03550 San Juan de Alicante, Spain.
Pathogens. 2025 Aug 20;14(8):824. doi: 10.3390/pathogens14080824.
In recent years, migratory movements have increased. This study aimed to compare tuberculosis cases in migrant and autochthonous patients. We conducted a retrospective analytical cohort study of patients diagnosed with tuberculosis in the Elda Health District (Alicante, Spain) between 2013 and 2023. Of the 98 patients analyzed, 28 (29.6%) were migrants, predominantly male (65%), with a mean age of 35.6 years. Pulmonary tuberculosis was present in 82% of patients in both groups, and nine cases of drug-resistant tuberculosis were identified. No significant differences were observed between groups in treatment cure rates, mortality, or hospitalization. Unfavourable outcomes-a composite endpoint comprising mortality, treatment failure, and loss to follow-up-were more frequent in males and in patients with elevated C-reactive protein (CRP) levels ( = 0.033) or a higher CRP/albumin ratio. Migrants accounted for a substantial proportion of total TB cases and tended to be younger, with fewer comorbidities and lower rates of substance use. They showed a non-significant trend toward higher loss to follow-up and drug resistance. Overall, unfavourable outcomes were associated with elevated CRP levels and the CRP/albumin ratio.
近年来，移民流动有所增加。本研究旨在比较移民患者和本地患者中的结核病病例。我们对2013年至2023年期间在埃尔达健康区（西班牙阿利坎特）被诊断为结核病的患者进行了一项回顾性分析队列研究。在分析的98例患者中，28例（29.6%）为移民，主要为男性（65%），平均年龄为35.6岁。两组中82%的患者患有肺结核，共发现9例耐多药结核病病例。两组在治疗治愈率、死亡率或住院率方面未观察到显著差异。不良结局——一个综合终点，包括死亡率、治疗失败和失访——在男性以及C反应蛋白（CRP）水平升高（P = 0.033）或CRP/白蛋白比值较高的患者中更为常见。移民占结核病总病例的很大比例，且往往更年轻，合并症较少，物质使用发生率较低。他们的失访率和耐药率有升高的趋势，但差异无统计学意义。总体而言，不良结局与CRP水平升高和CRP/白蛋白比值有关。
