Andreieva Iana, Tarnacka Beata, Zalewski Adam, Wiśniowska Justyna
Department of Rehabilitation Medicine, Faculty of Medicine, Warsaw Medical University, Spartańska 1, 02-637 Warsaw, Poland.
Department of Rehabilitation, Eleonora Reicher National Institute of Geriatrics, Rheumatology and Rehabilitation, Spartańska 1, 02-637 Warsaw, Poland.
Pharmaceuticals (Basel). 2025 Jul 25;18(8):1114. doi: 10.3390/ph18081114.
Complex regional pain syndrome (CRPS) is a disabling pain condition, which is distinct from other pain syndromes by the presence of autonomic dysfunction and regional inflammatory changes. To explore the impact of pharmacological treatment strategies, specifically scheduled, on-demand dosing regimens versus lack of medical treatment, on pain-related and functional outcomes in rehabilitation for individuals with CRPS. A total of 32 participants with CRPS were assigned to three treatment groups depending on analgesic treatment during the course of complex rehabilitation. Pre- and post-rehabilitation assessments were conducted using validated measures, including the Numerical Rating Scale (NRS) for pain, the Short-Form McGill Pain Questionnaire (SF-MPQ), PainDETECT, the Disabilities of the Arm, Shoulder, and Hand (DASH), and the Lower Extremity Functional Scale (LEFS). Significant improvements in pain and upper limb function (DASH scores) were observed across all groups ( < 0.05). No statistically significant changes were found in lower limb function (LEFS). Between-group comparisons revealed significant differences in post-treatment pain scores (SFMPQ-B), particularly between groups with a constant treatment regimen and those without treatment. There were no statistically significant changes compared to different treatment regimen groups. The constant treatment group showed slightly better average improvements in pain and disability compared to other groups. Statistically significant improvements in all CRPS patients were observed in pain-related and functional measures.
复杂性区域疼痛综合征（CRPS）是一种致残性疼痛疾病，它因存在自主神经功能障碍和局部炎症变化而有别于其他疼痛综合征。为探讨药物治疗策略，特别是定时按需给药方案与未接受治疗相比，对CRPS患者康复过程中疼痛相关及功能结局的影响。根据复杂康复过程中的镇痛治疗，将32例CRPS患者分为三个治疗组。康复前后评估采用经过验证的测量方法，包括疼痛数字评定量表（NRS）、简化麦吉尔疼痛问卷（SF-MPQ）、疼痛检测量表、上肢功能障碍量表（DASH）和下肢功能量表（LEFS）。所有组在疼痛和上肢功能（DASH评分）方面均有显著改善（<0.05）。下肢功能（LEFS）未发现统计学上的显著变化。组间比较显示治疗后疼痛评分（SFMPQ-B）存在显著差异，特别是在持续治疗方案组和未治疗组之间。与不同治疗方案组相比，未发现统计学上的显著变化。与其他组相比，持续治疗组在疼痛和残疾方面的平均改善略好。在所有CRPS患者中，疼痛相关及功能测量指标均有统计学上的显著改善。
