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疼痛管理的药理学方法:所用药物的叙述性综述

Pharmacological Methods of Pain Management: Narrative Review of Medication Used.

作者信息

Alorfi Nasser M

机构信息

Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.

出版信息

Int J Gen Med. 2023 Jul 31;16:3247-3256. doi: 10.2147/IJGM.S419239. eCollection 2023.

DOI:10.2147/IJGM.S419239
PMID:37546242
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10402723/
Abstract

BACKGROUND

Pain management is a critical aspect of healthcare, aimed at alleviating discomfort and improving the quality of life for individuals experiencing acute or chronic pain. Pharmacological methods constitute a primary approach to pain management, including a diverse array of drugs that work through different mechanisms.

AIM

Identifying medications commonly employed in pain management, focusing on their mechanism of actions, uses, efficacy and pharmacological applications.

METHODS

The methodology involved a systematic search of scientific literature using various databases, including PubMed, Scopus, and Google Scholar. Relevant articles published between 2000 and 2023 were screened for inclusion. The selected studies encompassed original research, review articles, therapeutic guidelines and randomized controlled trials.

RESULTS

The findings of this review suggest that a multimodal approach combining various analgesics can enhance pain relief while minimizing adverse effects. It emphasizes the importance of assessing pain intensity, determining the underlying etiology, and utilizing evidence-based guidelines to optimize pain management outcomes.

CONCLUSION

Pharmacological methods of pain management are an essential component of pain management strategies to achieve optimal pain relief while minimizing adverse effects. The article concludes with a discussion on emerging trends and future directions in pharmacological pain management, including novel drug targets and advances in drug delivery systems.

摘要

背景

疼痛管理是医疗保健的一个关键方面,旨在减轻不适并改善急性或慢性疼痛患者的生活质量。药理学方法是疼痛管理的主要途径,包括通过不同机制起作用的多种药物。

目的

确定疼痛管理中常用的药物,重点关注其作用机制、用途、疗效和药理学应用。

方法

该方法包括使用多个数据库(包括PubMed、Scopus和谷歌学术)对科学文献进行系统检索。筛选2000年至2023年发表的相关文章以纳入研究。所选研究包括原创研究、综述文章、治疗指南和随机对照试验。

结果

本综述的结果表明,结合多种镇痛药的多模式方法可以增强疼痛缓解效果,同时将不良反应降至最低。它强调了评估疼痛强度、确定潜在病因以及利用循证指南优化疼痛管理结果的重要性。

结论

疼痛管理的药理学方法是疼痛管理策略的重要组成部分,以实现最佳的疼痛缓解,同时将不良反应降至最低。文章最后讨论了药理学疼痛管理的新兴趋势和未来方向,包括新型药物靶点和药物递送系统的进展。

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