低剂量甲氨蝶呤对大鼠佐剂性关节炎影响的研究。
Studies on the effect of low dose methotrexate on rat adjuvant arthritis.
作者信息
Welles W L, Silkworth J, Oronsky A L, Kerwar S S, Galivan J
出版信息
J Rheumatol. 1985 Oct;12(5):904-6.
PMID:4087270
Abstract
Adjuvant arthritis in rats was induced by the intradermal administration of Freund's complete adjuvant. When these immunized rats were treated orally with low doses of methotrexate (150-600 micrograms/kg/week) a statistically significant suppression of paw inflammation was observed. This low dose of methotrexate was comparable to that used in the treatment of human rheumatoid arthritis (RA). Our results are the first demonstration of the efficacy of low dose methotrexate in an animal model of human RA.
摘要
通过皮内注射弗氏完全佐剂诱导大鼠佐剂性关节炎。当给这些免疫大鼠口服低剂量甲氨蝶呤（150 - 600微克/千克/周）时，观察到爪部炎症有统计学意义的抑制。这种低剂量甲氨蝶呤与用于治疗人类类风湿关节炎（RA）的剂量相当。我们的结果首次证明了低剂量甲氨蝶呤在人类RA动物模型中的疗效。
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