Elbehiry Ayman, Marzouk Eman
Department of Public Health, College of Applied Medical Sciences, Qassim University, P.O. Box 6666, Buraydah 51452, Saudi Arabia.
Vet Sci. 2025 Aug 13;12(8):757. doi: 10.3390/vetsci12080757.
Livestock-associated species-particularly (), (), and coagulase-negative staphylococci (CoNS)-pose escalating threats to animal health, food safety, and public health due to their evolving antimicrobial resistance (AMR) profiles. This review synthesizes recent insights into the molecular epidemiology, resistance determinants, and host adaptation strategies of these pathogens across food-producing animals. We highlight the role of mobile genetic elements (MGEs), clonal dissemination, and biofilm formation in shaping multidrug resistance (MDR) patterns. Diagnostic advancements, including MALDI-TOF MS, whole-genome sequencing (WGS), and PCR-based assays, are discussed alongside treatment challenges arising from therapeutic failures and limited vaccine efficacy. The review critically examines current AMR surveillance gaps and the need for integrative One Health frameworks that encompass animals, humans, and the environment. Novel tools such as metagenomics, real-time genomic surveillance, and artificial intelligence (AI)-driven analytics are proposed to enhance predictive monitoring and resistance management. Together, these insights underscore the urgency of coordinated, evidence-based interventions to curb the spread of MDR staphylococci and safeguard One Health.
与家畜相关的物种——尤其是（）、（）和凝固酶阴性葡萄球菌（CoNS）——由于其不断演变的抗菌药物耐药性（AMR）特征，对动物健康、食品安全和公共卫生构成了日益严重的威胁。本综述综合了近期对这些病原体在食用动物中的分子流行病学、耐药决定因素和宿主适应策略的见解。我们强调了移动遗传元件（MGEs）、克隆传播和生物膜形成在塑造多重耐药性（MDR）模式中的作用。讨论了诊断方面的进展，包括基质辅助激光解吸电离飞行时间质谱（MALDI-TOF MS）、全基因组测序（WGS）和基于聚合酶链反应（PCR）的检测方法，以及治疗失败和疫苗效力有限所带来的治疗挑战。本综述批判性地审视了当前AMR监测的差距以及建立涵盖动物、人类和环境的综合性“同一健康”框架的必要性。提出了宏基因组学、实时基因组监测和人工智能（AI）驱动的分析等新工具，以加强预测性监测和耐药性管理。总之，这些见解强调了采取协调一致、基于证据的干预措施来遏制多重耐药葡萄球菌传播并保障“同一健康”的紧迫性。
