Miyachi Y, Takigawa M
J Clin Lab Immunol. 1985 Nov;18(3):145-8.
To elucidate the mechanism(s) of persistent light reaction (PLR), i.e. persistent light reactivity to light that continues long after all exposure to the photosensitizing compound has ceased, mice were repeatedly photosensitized with 3, 3',4',5-tetrachlorosalicylanilide (TCSA) using a procedure developed by us. After 8 weeks' photosensitization, some mice reacted with black light (BL) irradiation alone without TCSA painting. This reaction peaked at 24hr after photoelicitation, comparable to the ordinary contact photosensitivity (CPS), and the reaction could be repeatedly elicited by BL exposure alone over a period of 6 months following sensitization. However, this reaction could not be transferred to naive syngenic mice via lymph node cells or spleen cells from PLR mice. From the results obtained in the present study, it seems unlikely that PLR was elicited by cells that were autophotosensitized to self carrier protein relating to photoproducts. A possible mechanism of PLR is discussed.
为阐明持续光反应（PLR）的机制，即对光敏化合物的所有暴露停止后仍持续很长时间的对光的持续光反应性，我们使用自行开发的程序，用3,3',4',5-四氯水杨酰苯胺（TCSA）对小鼠进行反复光敏化。在8周的光敏化后，一些小鼠仅在黑光（BL）照射下就有反应，而无需涂抹TCSA。该反应在光激发后24小时达到峰值，与普通接触性光敏反应（CPS）相当，并且在致敏后的6个月内，仅通过BL照射就可反复引发该反应。然而，这种反应不能通过PLR小鼠的淋巴结细胞或脾细胞转移给同基因的未致敏小鼠。根据本研究获得的结果，PLR似乎不太可能是由对与光产物相关的自身载体蛋白进行自敏化的细胞引发的。本文讨论了PLR的一种可能机制。
