Żukowicz-Wyrwa Wioletta Katarzyna, Markiet Karolina, Damps Tatsiana, Ciarka Aleksandra, Karaszewski Bartosz, Nowicki Roman
Department of Adult Neurology, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland.
Department of Adult Neurology, University Clinical Center in Gdansk, Gdansk, Poland.
Front Immunol. 2025 Aug 12;16:1595947. doi: 10.3389/fimmu.2025.1595947. eCollection 2025.
The article explores a case study of a patient diagnosed with relapsing-remitting multiple sclerosis (RRMS) who, while receiving treatment with the anti-CD20 monoclonal antibody ofatumumab, developed psoriatic skin lesions. Initially, sharply demarcated, scaly, erythematous lesions were observed only in the anogenital area. After several weeks, additional lesions appeared on the ear lobes, scalp, and lower legs following subsequent administrations of ofatumumab. A comprehensive differential diagnosis of the skin lesions was performed, which included consideration of autoimmune chronic diseases, infectious disease manifestations, and skin carcinomas. Biopsies of the lesions were obtained and underwent histopathological examination. Based on the clinical presentation and further investigations, it was concluded that the skin lesions were an atypical adverse reaction to ofatumumab, manifesting as psoriasis. In addition to presenting this case, we analyze the spectrum of common adverse reactions associated with ofatumumab, as well as the occurrence of psoriasis following other anti-CD20 therapies. To the best of our knowledge, this is a rare, documented instance of psoriasis occurring in a patient receiving ofatumumab for the treatment of multiple sclerosis.
本文探讨了一例复发缓解型多发性硬化症（RRMS）患者的病例研究，该患者在接受抗CD20单克隆抗体奥法妥木单抗治疗时出现了银屑病性皮肤病变。最初，仅在肛门生殖器区域观察到边界清晰、有鳞屑的红斑性病变。几周后，在后续使用奥法妥木单抗后，耳垂、头皮和小腿出现了额外的病变。对皮肤病变进行了全面的鉴别诊断，包括考虑自身免疫性慢性疾病、传染病表现和皮肤癌。获取了病变组织活检并进行了组织病理学检查。根据临床表现和进一步检查，得出结论认为皮肤病变是对奥法妥木单抗的非典型不良反应，表现为银屑病。除了呈现该病例外，我们还分析了与奥法妥木单抗相关的常见不良反应谱，以及其他抗CD20疗法后银屑病的发生情况。据我们所知，这是一例接受奥法妥木单抗治疗多发性硬化症的患者发生银屑病的罕见且有记录的病例。
