Chu Yi Ming, Zhang Hong, Huang Yeqiu, Li Jia, Huang Minmin
Department of Critical Care Medicine, Haimen District People's Hospital, Nantong, 226001, People's Republic of China.
Int J Nanomedicine. 2025 Aug 22;20:10213-10231. doi: 10.2147/IJN.S539190. eCollection 2025.
Healthcare systems worldwide face a significant challenge from nosocomial infections. These infections are associated with increased rates of disease, mortality, and healthcare expenses. Common issues with traditional treatment approaches include antibiotic resistance and inadequate pathogen targeting. Utilizing nanoparticles for the targeted administration of antimicrobial medications to infection areas has proven to enhance treatment outcomes while maintaining biocompatibility. Traditional diagnostic methods still rely on microbiological culture and susceptibility testing, while molecular technologies are seeing increased usage for rapid diagnosis. This review mainly aims to draw attention to the present state of nosocomial infections by outlining their prevalence and the ways in which nanotechnology is used to treat these illnesses. This study provides a thorough examination of the nanotherapeutic methods that have recently developed, with an emphasis on the clinical implications of different types of nanoparticles for the purpose of reducing the prevalence of nosocomial infectious diseases.
全球医疗保健系统面临着来自医院感染的重大挑战。这些感染与疾病发生率、死亡率和医疗费用的增加有关。传统治疗方法的常见问题包括抗生素耐药性和病原体靶向不足。事实证明,利用纳米颗粒将抗菌药物靶向输送到感染区域,在保持生物相容性的同时可提高治疗效果。传统诊断方法仍依赖微生物培养和药敏试验,而分子技术在快速诊断中的应用日益增加。本综述主要旨在通过概述医院感染的流行情况以及纳米技术用于治疗这些疾病的方式,引起人们对医院感染现状的关注。本研究对最近开发的纳米治疗方法进行了全面考察,重点关注不同类型纳米颗粒的临床意义,以降低医院感染性疾病的发生率。