Kwak In Hee, Ma Hyeo-Il, Kim Yun Joong, Noh Hye-Mi, Lee Jeongjae, Yu Je Kook, Kim Young Eun
Department of Neurology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Gyeonggi, South Korea.
Hallym Neurological Institute, Hallym University, Anyang, Gyeonggi, South Korea.
J Parkinsons Dis. 2025 Aug 28:1877718X251372392. doi: 10.1177/1877718X251372392.
BackgroundType 2 diabetes mellitus (DM) can influence the phenotype and progression of Parkinson's disease (PD), as both conditions share inflammation as a common pathogenic mechanism.ObjectiveTo explore peripheral inflammatory indices that reflect the impact of DM on PD.MethodsWe analyzed 52 drug-naïve PD patients with DM and 182 without DM, along with age- and sex-matched healthy control (HC) with and without DM in a 1:1 ratio. Clinical features were evaluated, including the Hoehn and Yahr (H&Y) scale and the Unified Parkinson's Disease Rating Scale (UPDRS). Peripheral inflammatory markers included the count of leukocyte subpopulations, high-density lipoprotein-cholesterol (HDL-C), and markers derived from these including neutrophil-to-HDL-C ratio (NHR), monocyte-to-HDL-C ratio (MHR), and lymphocyte-to-HDL-C ratio (LHR).ResultsThere were no significant differences in age, sex, or disease duration between PD with DM and PD without DM group. The PD with DM group showed more symmetric motor features ( 0.007) compared to the PD without DM group. NHR, MHR, and LHR were elevated in the PD with DM group compared to the other groups. Notably, MHR was highest in the PD with DM group, followed by the HC with DM group and the PD without DM group, and HC without DM group (9.73 vs. 8.30 vs. 7.63 vs. 6.46, 0.001). MHR positively correlated with clinical scales, including H&Y and UPDRS, across all PD patients ( < 0.05 for all).ConclusionsOur study suggests that MHR effectively reflects the peripheral inflammatory status related to both PD and diabetes.
背景
2型糖尿病（DM）可影响帕金森病（PD）的表型和病程，因为这两种疾病都有炎症作为共同的致病机制。
目的
探讨反映DM对PD影响的外周炎症指标。
方法
我们分析了52例未服用药物的合并DM的PD患者和182例未合并DM的PD患者，以及年龄和性别匹配的有DM和无DM的健康对照（HC），比例为1:1。评估临床特征，包括Hoehn和Yahr（H&Y）量表以及统一帕金森病评定量表（UPDRS）。外周炎症标志物包括白细胞亚群计数、高密度脂蛋白胆固醇（HDL-C），以及从中衍生的标志物，包括中性粒细胞与HDL-C比值（NHR）、单核细胞与HDL-C比值（MHR）和淋巴细胞与HDL-C比值（LHR）。
结果
合并DM的PD组和未合并DM的PD组在年龄、性别或病程方面无显著差异。与未合并DM的PD组相比，合并DM的PD组表现出更对称的运动特征（P = 0.007）。与其他组相比，合并DM的PD组的NHR、MHR和LHR升高。值得注意的是，合并DM的PD组的MHR最高，其次是合并DM的HC组、未合并DM的PD组和未合并DM的HC组（9.73对8.30对7.63对6.46，P = 0.001）。在所有PD患者中，MHR与临床量表（包括H&Y和UPDRS）呈正相关（所有P均<0.05）。
结论
我们的研究表明，MHR有效地反映了与PD和糖尿病相关的外周炎症状态。
