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2
Risk factors associated with preterm birth among mothers delivered at Lira Regional Referral Hospital.与利拉地区转诊医院产妇早产相关的风险因素。
BMC Pregnancy Childbirth. 2023 Nov 23;23(1):814. doi: 10.1186/s12884-023-06120-4.
3
National, regional, and global estimates of preterm birth in 2020, with trends from 2010: a systematic analysis.2020 年全球、区域和国家早产估计数及其 2010 年以来的变化趋势：系统分析。
Lancet. 2023 Oct 7;402(10409):1261-1271. doi: 10.1016/S0140-6736(23)00878-4.
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Interventions for malaria prevention in pregnancy; factors influencing uptake and their effect on pregnancy outcomes among post-natal women in a tertiary facility in the Volta Region of Ghana.加纳沃尔特地区一家三级医疗机构中针对孕期疟疾预防的干预措施；影响产后妇女接受程度的因素及其对妊娠结局的影响
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9
A Scoping Review of Preterm Births in Sub-Saharan Africa: Burden, Risk Factors and Outcomes.撒哈拉以南非洲早产儿的范围综述：负担、风险因素和结局。
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Prevalence and Risk Factors of Preterm Birth Among Pregnant Women Admitted at the Labor Ward of the Komfo Anokye Teaching Hospital, Ghana.加纳Komfo Anokye教学医院产房收治孕妇的早产患病率及危险因素
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加纳一家三级医疗机构中早产活产的发生率、危险因素及结局

Incidence, risk factors and outcomes of preterm live births in a tertiary health facility in Ghana.

作者信息

Dah Anthony Kwame, Osarfo Joseph, Mbroh Hintermann, Ampofo Gifty Dufie, Appiah-Kubi Adu, Azanu Wisdom Klutse, Amoh Michael, Morhe Emmanuel Senanu Komla

机构信息

Department of Obstetrics and Gynaecology, School of Medicine, University of Health and Allied Sciences, Ho, Volta Region, Ghana.

Department of Obstetrics and Gynaecology, Ho Teaching Hospital, Ho, Volta Region, Ghana.

出版信息

PLoS One. 2025 Aug 28;20(8):e0331223. doi: 10.1371/journal.pone.0331223. eCollection 2025.

DOI:10.1371/journal.pone.0331223
PMID:40875642
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12393770/
Abstract

OBJECTIVES

Accurate measures of the burden of preterm live births are a challenge, particularly in low-and-middle income countries, due to factors including poor data quality and unreliable methods using last menstrual period (LMP) in determining gestational age of pregnancies. This study employed gestational age from first trimester ultrasound to determine incidence of preterm livebirths at Ho Teaching Hospital in Ghana, their risk factors and adverse outcomes.

METHODS

This was a prospective study involving 666 pregnant women and their 680 live newborns from 1st October, 2019-31st March, 2020. Data was collected on socio-demographic characteristics such as age and for other variables including gestational age at delivery and birthweight. The primary outcome was overall preterm livebirth incidence. Logistic regression analysis was used to determine its predictors. Odds ratios were reported with 95% confidence intervals. Statistical significance was pegged at p-value <0.05.

RESULTS

The mean age of the women was 29.0 years. About 93% (616/666) had formal education. Overall preterm livebirth incidence was 9.1% (62/680). Formal employment [AOR 6.84 (95% CI 1.63-28.73), p = 0.009], informal employment [AOR 4.98 (95% CI 1.39-17.85), p = 0.014] and hypertensive disorders in pregnancy (HDP) [AOR 6.43(95% CI 2.78-14.89); p < 0.001] increased the odds of preterm livebirth. Adequate antenatal clinic contacts (ANC) [AOR 0.14 (95% CI 0.05-0.37), p < 0.001] and doses of sulphadoxine-pyrimethamine for malaria prevention in pregnancy (IPTp) [AOR 0.21(0.10-0.45), p < 0.001] reduced the odds of preterm livebirth by 86% and 79% respectively.

CONCLUSION

Overall preterm livebirth incidence in the study compared favourably with global estimates. HDP and being employed were important risk factors and. suggest reducing workloads of pregnant women in formal employment may be beneficial. Targeted posting of specialists to aid adequate management of HDP at district hospitals and mitigating missed opportunities for IPTp need to be considered.

摘要

目的

准确衡量早产活产的负担是一项挑战，尤其是在低收入和中等收入国家，这是由于数据质量差以及使用末次月经日期（LMP）确定妊娠孕周的方法不可靠等因素所致。本研究采用孕早期超声确定的孕周来确定加纳霍教学医院的早产活产发生率、危险因素及不良结局。

方法

这是一项前瞻性研究，纳入了2019年10月1日至2020年3月31日期间的666名孕妇及其680例活产新生儿。收集了社会人口学特征数据，如年龄，以及其他变量，包括分娩时的孕周和出生体重。主要结局是总体早产活产发生率。采用逻辑回归分析确定其预测因素。报告比值比及95%置信区间。统计学显著性设定为p值<0.05。

结果

女性的平均年龄为29.0岁。约93%（616/666）接受过正规教育。总体早产活产发生率为9.