氯化L-肉碱及其乙酰化衍生物对棕榈酰-L-肉碱诱导的离体犬心室肌电生理紊乱的影响。

Effect of l-carnitine chloride and its acetyl derivative on the electrophysiological derangement induced by palmityl-l-carnitine in isolated canine ventricular muscle.

作者信息

Matsui K, Nakazawa M, Takeda K, Imai S

出版信息

Jpn J Pharmacol. 1985 Oct;39(2):263-70. doi: 10.1254/jjp.39.263.

DOI:10.1254/jjp.39.263

Abstract

Using the microelectrode technique, the effects of l-carnitine (LC) and acetyl-l-carnitine (ALC) on the changes in the transmembrane action potential of the canine ventricular muscle induced by palmityl-l-carnitine (PLC) were studied in comparison with those of disopyramide (D). LC (5 X 10(-3) M) itself had no effect on the electrophysiological parameters of the ventricular muscle. ALC (5 X 10(-3) M) increased the maximum rate of rise (dV/dt max) slightly and decreased the action potential duration (APD), although these changes were not statistically significant. D (1.5 X 10(-3) M) decreased dV/dt max and prolonged APD and the absolute refractory period (ARP). PLC (3 X 10(-4) M) decreased the resting membrane potential, action potential amplitude and dV/dt max, and it shortened APD and ARP. LC and ALC (5 X 10(-3) M) improved the electrophysiological derangement produced by PLC to the same degree. On the other hand, application of D (1.5 X 10(-5) M) resulted in no improvement of the electrophysiological derangement produced by PLC.

摘要

采用微电极技术，研究了左旋肉碱（LC）和乙酰左旋肉碱（ALC）对棕榈酰左旋肉碱（PLC）诱导的犬心室肌跨膜动作电位变化的影响，并与丙吡胺（D）进行比较。LC（5×10⁻³M）本身对心室肌电生理参数无影响。ALC（5×10⁻³M）使最大上升速率（dV/dt max）略有增加，动作电位时程（APD）缩短，尽管这些变化无统计学意义。D（1.5×10⁻³M）使dV/dt max降低，APD和绝对不应期（ARP）延长。PLC（3×10⁻⁴M）使静息膜电位、动作电位幅度和dV/dt max降低，APD和ARP缩短。LC和ALC（5×10⁻³M）对PLC引起的电生理紊乱的改善程度相同。另一方面，应用D（1.5×10⁻⁵M）对PLC引起的电生理紊乱无改善作用。