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Cancer-derived mitochondria fuel fibroblasts to become pro-tumorigenic.

作者信息

Delitto Daniel, Longaker Michael T

机构信息

Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.

Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.

出版信息

Nat Cancer. 2025 Aug 28. doi: 10.1038/s43018-025-01005-1.

DOI:10.1038/s43018-025-01005-1
PMID:40877412
Abstract
摘要

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本文引用的文献

1
MIRO2 promotes cancer invasion and metastasis via MYO9B suppression of RhoA activity.MIRO2通过MYO9B对RhoA活性的抑制促进癌症侵袭和转移。
Cell Rep. 2025 Jan 28;44(1):115120. doi: 10.1016/j.celrep.2024.115120. Epub 2024 Dec 24.
2
Mitochondrial Transfer as a Strategy for Enhancing Cancer Cell Fitness:Current Insights and Future Directions.线粒体转移作为增强癌细胞适应性的策略：当前的见解和未来的方向。
Pharmacol Res. 2024 Oct;208:107382. doi: 10.1016/j.phrs.2024.107382. Epub 2024 Aug 30.
3
Hematoxylin and Eosin Architecture Uncovers Clinically Divergent Niches in Pancreatic Cancer.
苏木精和伊红染色结构揭示胰腺癌中具有临床差异的龛位。
Tissue Eng Part A. 2024 Oct;30(19-20):605-613. doi: 10.1089/ten.TEA.2024.0039. Epub 2024 Jul 1.
4
Desmoplastic stromal signatures predict patient outcomes in pancreatic ductal adenocarcinoma.促结缔组织增生性基质特征可预测胰腺导管腺癌患者的预后。
Cell Rep Med. 2023 Nov 21;4(11):101248. doi: 10.1016/j.xcrm.2023.101248. Epub 2023 Oct 20.
5
Multiomic analysis reveals conservation of cancer-associated fibroblast phenotypes across species and tissue of origin.多组学分析揭示了癌症相关成纤维细胞表型在物种和组织起源上的保守性。
Cancer Cell. 2022 Nov 14;40(11):1392-1406.e7. doi: 10.1016/j.ccell.2022.09.015. Epub 2022 Oct 20.
6
MIRO2 Regulates Prostate Cancer Cell Growth via GCN1-Dependent Stress Signaling.MIRO2 通过 GCN1 依赖的应激信号调控前列腺癌细胞生长。
Mol Cancer Res. 2022 Apr 1;20(4):607-621. doi: 10.1158/1541-7786.MCR-21-0374.
7
Intercellular nanotubes mediate mitochondrial trafficking between cancer and immune cells.细胞间纳米管介导癌细胞和免疫细胞之间的线粒体运输。
Nat Nanotechnol. 2022 Jan;17(1):98-106. doi: 10.1038/s41565-021-01000-4. Epub 2021 Nov 18.
8
Cancer metastasis as a non-healing wound.癌症转移如同无法愈合的创伤。
Br J Cancer. 2021 Apr;124(9):1491-1502. doi: 10.1038/s41416-021-01309-w. Epub 2021 Mar 17.
9
Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts.跨物种胰腺导管腺癌单细胞分析揭示了抗原呈递的癌相关成纤维细胞。
Cancer Discov. 2019 Aug;9(8):1102-1123. doi: 10.1158/2159-8290.CD-19-0094. Epub 2019 Jun 13.
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Cancer Discov. 2019 Feb;9(2):282-301. doi: 10.1158/2159-8290.CD-18-0710. Epub 2018 Oct 26.