通过包括依拉环素在内的联合疗法有效管理血液系统恶性肿瘤伴长期严重粒细胞缺乏症患者合并器官播散的耐碳青霉烯类肠杆菌血流感染
Effective Management of Carbapenem-Resistant Enterobacterales Bloodstream Infection with Organ Dissemination in Prolonged Severe Agranulocytosis Patients with Hematological Malignancy Through Combination Therapies Including Eravacycline.
作者信息
Lv Yuyuan, Zhang Xin, Cui Qingya, Li Mengyun, Bai Lian, Yu Yan, Li XueKai, Chen Xiaoqian, Wu Depei, Tang Xiaowen
机构信息
National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
出版信息
Infect Dis Ther. 2025 Aug 28. doi: 10.1007/s40121-025-01206-2.
This study reports three patients with hematologic malignancy patients and Carbapenem-resistant Enterobacterales (CRE) bloodstream infections and organ dissemination during neutropenia. After failed conventional therapy, a novel "through Combination therapies including eravacycline" regimen achieved fever control within 10 days and lesion resolution by 20 days approximately, demonstrating breakthrough efficacy for CRE bacteremia management.
本研究报告了3例血液系统恶性肿瘤患者，在中性粒细胞减少期间发生了耐碳青霉烯类肠杆菌科细菌（CRE）血流感染及器官播散。在传统治疗失败后，一种新型的“包括依拉环素在内的联合治疗”方案在10天内实现了发热控制，约20天时病变消退，显示出在治疗CRE菌血症方面的突破性疗效。
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