Floeder Joseph R, Jeong Huijeong, Mohebi Ali, Namboodiri Vijay Mohan K
Neuroscience Graduate Program, University of California, San Francisco, San Francisco, United States.
Department of Neurology, University of California, San Francisco, San Francisco, United States.
Elife. 2025 Aug 29;13:RP98666. doi: 10.7554/eLife.98666.
Mesolimbic dopamine activity occasionally exhibits ramping dynamics, reigniting debate on theories of dopamine signaling. This debate is ongoing partly because the experimental conditions under which dopamine ramps emerge remain poorly understood. Here, we show that during Pavlovian and instrumental conditioning in mice, mesolimbic dopamine ramps are only observed when the inter-trial interval is short relative to the trial period. These results constrain theories of dopamine signaling and identify a critical variable determining the emergence of dopamine ramps.
中脑边缘多巴胺活动偶尔会呈现出斜坡状动态变化，这重新引发了关于多巴胺信号传导理论的争论。这场争论仍在继续，部分原因是多巴胺斜坡出现的实验条件仍未得到充分理解。在这里，我们表明，在小鼠的巴甫洛夫条件反射和操作性条件反射过程中，只有当试验间隔相对于试验期较短时，才会观察到中脑边缘多巴胺斜坡。这些结果限制了多巴胺信号传导理论，并确定了一个决定多巴胺斜坡出现的关键变量。
