Haye Sidra, Ferido Patricia, Jacobson Mireille
USC Price School of Public Policy, University of Southern California, Los Angeles, California, USA.
Leonard D. Schaeffer Center for Health Policy & Economics, University of Southern California, Los Angeles, California, USA.
Alzheimers Dement. 2025 Jul;21(7):e70517. doi: 10.1002/alz.70517.
Racial and ethnic disparities in clinical research, although documented in aggregate, are poorly understood due to a lack of data on the population eligible to participate. We compared the characteristics of Medicare beneficiaries who participated in the Imaging Dementia-Evidence for Amyloid Scanning (IDEAS) study to those eligible to participate.
We used 100% Medicare claims data from 2016 to 2017 to identify IDEAS study participants and those eligible to participate.
We identified 11,480 beneficiaries in the IDEAS study sample and 3,008,067 in the eligible sample. Participants were more likely to reside in urban areas, less likely to be enrolled in both Medicare and Medicaid, or a Medicare Advantage plan. Black and Hispanic participants were more likely to reside in higher-income counties and were healthier than the eligible sample.
Racial and ethnic minority participants in clinical research differ from those eligible, particularly in socioeconomic and insurance characteristics, affecting generalizability.
In this study, we compared the characteristics of Medicare beneficiaries participating in the Imaging Dementia-Evidence for Amyloid Scanning (IDEAS) study and Medicare beneficiaries eligible to participate in the IDEAS study. We use 100% claims of Medicare beneficiaries. Hispanic and Black beneficiaries in the IDEAS study participant sample were more likely to reside in an urban area, less likely to be dually enrolled in Medicare and Medicaid, and more likely to reside in a county with higher income compared to the Hispanic and Black beneficiaries IDEAS eligible sample. Across racial/ethnic groups, IDEAS study participants were more likely to be enrolled in Traditional Medicare compared to the IDEAS eligible sample.
临床研究中的种族和民族差异虽然有总体记录，但由于缺乏关于符合参与条件人群的数据，人们对此了解甚少。我们比较了参与淀粉样蛋白扫描痴呆成像证据（IDEAS）研究的医疗保险受益人与有资格参与该研究的人员的特征。
我们使用了2016年至2017年100%的医疗保险理赔数据来确定IDEAS研究的参与者和有资格参与的人员。
我们在IDEAS研究样本中确定了11480名受益人，在符合条件的样本中有3008067名。参与者更有可能居住在城市地区，同时参加医疗保险和医疗补助或医疗保险优势计划的可能性较小。黑人和西班牙裔参与者更有可能居住在高收入县，并且比符合条件的样本更健康。
临床研究中的种族和少数民族参与者与有资格参与的人员不同，特别是在社会经济和保险特征方面，这影响了研究结果的普遍性。
在本研究中，我们比较了参与淀粉样蛋白扫描痴呆成像证据（IDEAS）研究的医疗保险受益人与有资格参与IDEAS研究的医疗保险受益人的特征。我们使用了医疗保险受益人的100%理赔数据。与符合IDEAS条件的西班牙裔和黑人受益人样本相比，IDEAS研究参与者样本中的西班牙裔和黑人受益人更有可能居住在城市地区，同时参加医疗保险和医疗补助的可能性较小，并且更有可能居住在高收入县。在所有种族/民族群体中，与符合IDEAS条件的样本相比，IDEAS研究参与者更有可能参加传统医疗保险。
