Farajpour Neda, Soraya Hamid
Experimental and Applied Pharmaceutical Sciences Research Center, Urmia University of Medical Sciences, Urmia, Iran.
Department of Pharmacology and Toxicology, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.
Neurodegener Dis Manag. 2025 Aug 29:1-9. doi: 10.1080/17582024.2025.2554374.
Alzheimer's disease is a neurodegenerative condition characterized by memory deficits and cognitive decline. Ivermectin, an antiparasitic agent, has shown neuroprotective effects. The present study was conducted to determine the protective effects of ivermectin in a streptozocin-induced Alzheimer's model in rats.
Alzheimer's model was induced by bilateral intracerebroventricular injection of streptozocin (3 mg/kg BW, 2 doses). Ivermectin was administered intraperitoneally at a dose of 2 mg/kg. On day 19, after behavioral memory and learning tests, the samples were collected for histological and enzymatic studies.
Ivermectin reduced the histopathological changes, including pyknotic and dead neurons and the accumulation of Aβ plaques. Ivermectin administration also reduced serum ( < 0.0001) and brain tissue ( < 0.01) acetylcholinesterase activity as well as improved learning ( < 0.05) and spatial memory ( < 0.0001).
Ivermectin demonstrates protective effects in the STZ-induced Alzheimer's model by reducing pathological changes and Aβ plaques, acetylcholinesterase activity, as well as improving memory and learning.
阿尔茨海默病是一种以记忆缺陷和认知衰退为特征的神经退行性疾病。伊维菌素是一种抗寄生虫药物，已显示出神经保护作用。本研究旨在确定伊维菌素在链脲佐菌素诱导的大鼠阿尔茨海默病模型中的保护作用。
通过双侧脑室内注射链脲佐菌素（3mg/kg体重，2剂）诱导阿尔茨海默病模型。伊维菌素以2mg/kg的剂量腹腔注射。在第19天，进行行为记忆和学习测试后，收集样本进行组织学和酶学研究。
伊维菌素减少了组织病理学变化，包括固缩和死亡的神经元以及Aβ斑块的积累。给予伊维菌素还降低了血清（<0.0001）和脑组织（<0.01）中的乙酰胆碱酯酶活性，并改善了学习能力（<0.05）和空间记忆（<0.0001）。
伊维菌素通过减少病理变化、Aβ斑块、乙酰胆碱酯酶活性，并改善记忆和学习能力，在链脲佐菌素诱导的阿尔茨海默病模型中显示出保护作用。
