Gureev A P, Babenkova P I, Nesterova V V, Volodina D E, Sadovnikova I S, Starodubtsev K A, Ivanov M E, Silachev D N, Plotnikov E Yu
Voronezh State University, Voronezh, Russia.
A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
Bull Exp Biol Med. 2025 Aug 29. doi: 10.1007/s10517-025-06458-z.
The levels of inflammatory markers increased in both mouse blood plasma and affected brain area 24 days after traumatic brain injury, which was accompanied by impairment of spatial working memory. Methylene blue administered during the first 3 days after injury reduced the levels of some inflammation markers and increased the expression of genes involved in the regulation of mitochondrial biogenesis and mitophagy, i.e. genes responsible for mitochondrial quality control. Additionally, methylene blue partially mitigated the cognitive deficits induced by the injury, suggesting it as a promising compound for maintaining brain function after traumas.
创伤性脑损伤24天后，小鼠血浆和受影响脑区的炎症标志物水平均升高，同时伴有空间工作记忆受损。损伤后前3天给予亚甲蓝可降低一些炎症标志物的水平，并增加参与线粒体生物发生和线粒体自噬调节的基因的表达，即负责线粒体质量控制的基因。此外，亚甲蓝部分减轻了损伤诱导的认知缺陷，表明它是创伤后维持脑功能的一种有前景的化合物。
