Stelmashook E V, Genrikhs E E, Mukhaleva E V, Kapkaeva M R, Kondratenko R V, Skrebitsky V G, Isaev N K
Research Center of Neurology, Moscow, Russia.
M. V. Lomonosov Moscow State University, Moscow, Russia.
Bull Exp Biol Med. 2019 Aug;167(4):455-459. doi: 10.1007/s10517-019-04548-3. Epub 2019 Sep 6.
Focal unilateral traumatic brain injury in the sensorimotor cortical region disturbed the functions of contralateral limbs controlled by the damaged hemisphere. A single intravenous injection of methylene blue (1 mg/kg) immediately before or 30 min after the injury significantly weakened functional disorders in the affected extremities. In vitro experiments showed that methylene blue effectively reduced death of cultured neurons provoked by paraquat or zinc ions producing the toxic effects on mitochondrias.
感觉运动皮质区域的局灶性单侧创伤性脑损伤扰乱了受损半球所控制的对侧肢体的功能。在损伤前即刻或损伤后30分钟单次静脉注射亚甲蓝（1毫克/千克）可显著减轻受影响肢体的功能障碍。体外实验表明，亚甲蓝可有效减少由百草枯或锌离子对线粒体产生毒性作用所引发的培养神经元死亡。
