定期补充葡萄糖胺与年龄相关慢性病风险：倾向评分匹配队列研究的证据

Regular glucosamine supplementation and risk of age-related chronic diseases: evidence from a propensity score-matched cohort study.

作者信息

He Jing, Ma Yue, Jiang Yan, Ji Jianguang, Song Fengju

机构信息

Department of Epidemiology and Biostatistics, Key Laboratory of Molecular Cancer Epidemiology, Key Laboratory of Prevention and Control of Major Diseases in the Population, Tianjin's Clinical Research Center for Cancer, Ministry of Education, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, 300060, China.

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, United States of America.

出版信息

Aging Clin Exp Res. 2025 Aug 29;37(1):259. doi: 10.1007/s40520-025-03171-9.

DOI:10.1007/s40520-025-03171-9

PMID:40879960

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12397181/

Abstract

BACKGROUND

Glucosamine is a widely used dietary supplement, particularly among middle-aged and older adults, with potential health benefits beyond joint health. However, its potential role in the prevention of chronic diseases remains uncertain.

AIMS

To investigate the association between regular glucosamine use and the risk of age-related non-communicable diseases (NCDs) in a large prospective cohort.

METHODS

269,033 participants in the large prospective cohort (UK Biobank) without NCDs at baseline were included. 1:1 propensity-score matching (PSM) was used to match glucosamine users with non-users. Cox proportional hazard regression was used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs).

RESULTS

During a median follow-up of 13.8 years, 52,556 participants reported regular glucosamine use. After PSM, 52,525 users and 52,525 non-users were included in the matched cohort. After false discovery rate correction, regular glucosamine use was associated with a significantly lower risk of seven NCDs: esophageal cancer (HR, 0.73; 95% CI, 0.58-0.92), gout (HR, 0.81; 95% CI, 0.72-0.91), chronic obstructive pulmonary disease (HR, 0.86; 95% CI, 0.80-0.93), colorectal cancer (HR, 0.86; 95% CI, 0.78-0.94), chronic liver disease (HR, 0.87; 95% CI, 0.80-0.94), heart failure (HR, 0.88; 95% CI, 0.81-0.96), and coronary heart disease (HR, 0.92; 95% CI, 0.88-0.96).

CONCLUSIONS

Regular use of glucosamine was associated with a reduced risk of several age-related chronic diseases. Further studies are needed to confirm these findings and to clarify its potential role in supporting healthy aging.

摘要

背景

氨基葡萄糖是一种广泛使用的膳食补充剂，尤其在中老年人中，它除了对关节健康有益外，还可能带来其他健康益处。然而，其在预防慢性病方面的潜在作用仍不明确。

目的

在一个大型前瞻性队列中研究定期使用氨基葡萄糖与年龄相关的非传染性疾病（NCDs）风险之间的关联。

方法

纳入大型前瞻性队列（英国生物银行）中269,033名基线时无NCDs的参与者。采用1:1倾向评分匹配（PSM）将氨基葡萄糖使用者与非使用者进行匹配。使用Cox比例风险回归来估计风险比（HRs）和95%置信区间（CIs）。

结果

在中位随访13.8年期间，52,556名参与者报告定期使用氨基葡萄糖。PSM后，匹配队列中纳入了52,525名使用者和52,525名非使用者。经过错误发现率校正后，定期使用氨基葡萄糖与七种NCDs风险显著降低相关：食管癌（HR，0.73；95% CI，0.58 - 0.92）、痛风（HR，0.81；95% CI，0.72 - 0.91）、慢性阻塞性肺疾病（HR，0.86；95% CI，0.80 - 0.93）、结直肠癌（HR，0.86；95% CI，0.78 - 0.94）、慢性肝病（HR，0.87；95% CI，0.80 - 0.94）、心力衰竭（HR，0.88；95% CI，0.81 - 0.96）和冠心病（HR，0.92；95% CI，0.88 - 0.96）。