Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Department of Social Medicine and Health Service Management, Shenzhen University, Shenzhen, China.
J Gerontol A Biol Sci Med Sci. 2024 Feb 1;79(2). doi: 10.1093/gerona/glad123.
We investigated the associations between habitual use of glucosamine and incident dementia and Parkinson's disease in a population-based cohort.
Using the UK Biobank data, we included around 0.29 million middle- to old-aged participants free of dementia or Parkinson's disease at baseline. Glucosamine supplementation was measured by questionnaire at baseline. Some participants additionally answered 1-5 rounds of 24-hour dietary recalls afterwards, particularly 112 243 participants (for dementia) and 112 084 (for Parkinson's disease). Incident cases of dementia and Parkinson's disease were identified through linkage to health administrative data sets. We examined the associations of glucosamine supplementation with incident dementia and Parkinson's disease using Cox proportional-hazards regression models with adjustment for various covariates.
During the study period (median follow-up: 9.1-10.9 years), 4 404 and 1 637 participants developed dementia and Parkinson's disease, respectively. Glucosamine intake was not associated with incident dementia or Parkinson's disease. In fully adjusted models, the hazard ratios associated with glucosamine intake were 1.06 [95% confidence interval (CI): 0.99, 1.14] for dementia and 0.97(95% CI: 0.86, 1.09) for Parkinson's disease. In the subsample, similar results were found as the frequency of reported glucosamine use over multiple dietary surveys was associated with neither of the 2 conditions.
Habitual supplementation of glucosamine was not associated with incident dementia or Parkinson's disease.
我们在一项基于人群的队列研究中调查了习惯性使用氨基葡萄糖与痴呆和帕金森病发病的相关性。
利用英国生物库数据，我们纳入了约 29 万名基线时无痴呆或帕金森病的中老年人。基线时通过问卷测量氨基葡萄糖补充情况。随后部分参与者还回答了 1-5 轮 24 小时膳食回忆，特别是 112243 名参与者（用于痴呆）和 112084 名参与者（用于帕金森病）。通过与健康管理数据集的链接来确定痴呆和帕金森病的发病情况。我们使用 Cox 比例风险回归模型，在调整了各种协变量后，研究了氨基葡萄糖补充与痴呆和帕金森病发病的相关性。
在研究期间（中位随访时间：9.1-10.9 年），分别有 4404 名和 1637 名参与者发生痴呆和帕金森病。氨基葡萄糖摄入与痴呆或帕金森病发病无关。在完全调整的模型中，与氨基葡萄糖摄入相关的风险比分别为痴呆的 1.06（95%置信区间：0.99，1.14）和帕金森病的 0.97（95%置信区间：0.86，1.09）。在亚样本中，也发现了类似的结果，因为多次膳食调查中报告的氨基葡萄糖使用频率与这两种疾病均无关。
习惯性补充氨基葡萄糖与痴呆或帕金森病的发病无关。
