Charieras J L, de Broca A
Med Trop (Mars). 1985 Oct-Dec;45(4):413-22.
97 cases of typhoïd fever in child are reported. This disease remains frequent and even severe in tropical zone where its evolution is of endemoepidemic type. Established fever, in spite of an appropriate treatment, is one of the main features of this disease. A certain number of clinical signs call for it; although classical, some others are less significant. Complications are frequent, without any correlation between the date of hospitalizing and the beginning of the disease. They are sometimes severe but mortality rate during hospitalization is quite low. Leukoneutropenia and thrombopenia are both exceptional. Blood culture and serology are always the background of any diagnosis, the latter appearing to the authors much more valuable than the former. Sulfamethoxazole-trimethoprime is an antibiotic to be recommended in first instance. Precocity of treatment has no influence on the time of apyrexia is appearing. If hopes put on oral vaccine could be confirmed, so it might be used on a large scale for children living in endemia zones.
报告了97例儿童伤寒病例。在热带地区，这种疾病仍然常见，甚至严重，其流行呈地方性流行类型。尽管进行了适当治疗，但持续发热仍是该疾病的主要特征之一。有一些临床症状提示该病；虽然有些是典型症状，但其他一些症状则不太明显。并发症很常见，住院日期与疾病开始时间之间没有任何关联。并发症有时很严重，但住院期间的死亡率相当低。白细胞减少和血小板减少都很罕见。血培养和血清学始终是任何诊断的基础，作者认为血清学比血培养更有价值。磺胺甲恶唑-甲氧苄啶是首先推荐使用的抗生素。治疗的及时性对退热时间没有影响。如果对口服疫苗的期望能够得到证实，那么它可能会在地方性流行区的儿童中大规模使用。
