Ai Mao-Mao, Lin Tao, Guo Ruo-Yu, Zhang Ying-Ying, Yu Feng
Department of Otorhinolaryngology-Head and Neck Surgery, Guangzhou Red Gross Hospital, Guangzhou 510220, Guangdong Province, China.
World J Clin Cases. 2025 Sep 6;13(25):107471. doi: 10.12998/wjcc.v13.i25.107471.
Thyroid cartilage noncontiguous metastatic involvement is an extremely rare entity due to the absence of vessels within the cartilaginous tissue. A literature review revealed that metastasis from lung cancer is even rarer.
A 51-year-old male smoker presented with progressive, painful left upper neck lumps for 8 months, accompanied by 10 kg weight loss, poor appetite, and mentation. He had a 30-year history of chronic alcohol use. Following comprehensive imaging studies and pathological examinations, we have identified metastatic lung adenocarcinoma with widespread dissemination to multiple sites including the thyroid cartilage. The final diagnosis is: Lung adenocarcinoma (pT3N3M1c, Stage IVb), epidermal growth factor receptor-mutated (p.E746_S752delinsV). After multidisciplinary team discussion, the patient was initiated on targeted therapy with gefitinib (250 mg/day). At 6-month follow-up, the patient has shown significant clinical improvement with marked reduction in subcutaneous masses in both the cervical and abdominal regions.
Monitor for uncommon thyroid cartilage noncontiguous metastases; early detection improves outcomes.
由于软骨组织内无血管，甲状腺软骨非连续性转移受累是一种极其罕见的情况。文献综述显示，肺癌转移更为罕见。
一名51岁男性吸烟者，左上颈部肿块进行性疼痛8个月，伴有体重减轻10公斤、食欲减退和精神状态不佳。他有30年慢性饮酒史。经过全面的影像学检查和病理检查，我们确诊为转移性肺腺癌，广泛播散至包括甲状腺软骨在内的多个部位。最终诊断为：肺腺癌（pT3N3M1c，IVb期），表皮生长因子受体突变（p.E746_S752delinsV）。多学科团队讨论后，患者开始接受吉非替尼靶向治疗（250毫克/天）。在6个月的随访中，患者临床症状明显改善，颈部和腹部皮下肿块明显缩小。
监测罕见的甲状腺软骨非连续性转移；早期发现可改善预后。
