超声造影剂（声诺维）与放射造影剂（碘美伦）用于头颈部病变内注射的比较：一项体外研究
Comparison of ultrasonographic (SonoVue) and radiographic (Imeron) contrast agents for intralesional application in the head and neck area: An in vitro study.
作者信息
Lentge Fritjof, Korn Philippe, Gellrich Nils-Claudius, Neuhaus Michael-Tobias, Bettag Stephan Alexander, Linderkamp Max Lukas, Jehn Philipp
机构信息
Department of Oral and Maxillofacial Surgery, Hannover Medical School, Hannover, Germany.
出版信息
Ultrasound. 2025 Aug 25:1742271X251365429. doi: 10.1177/1742271X251365429.
PURPOSE
This study aimed to determine the suitability and optimal concentration of an ultrasonic contrast agent (SonoVue) for intralesional application during contrast-enhanced ultrasonography (CEUS).
METHODS
An in vitro model simulating an existing lesion in the anatomical environment of the mandibular ascending ramus was developed. After intralesional application, different SonoVue dilutions were compared with dilutions of an iodine-containing radiographic contrast agent (Imeron300) during cone-beam computed tomography.
CONCLUSIONS
SonoVue provided a significant contrast effect for distinguishing the lesion from the surrounding soft tissue at dilutions of 1/10 and 1/20. Imeron300 showed a slightly superior contrast effect, even at dilutions of 1/50 and 1/100. However, CEUS using SonoVue in low dilutions seemed suitable for intralesional application in vitro. Further in vivo studies are required to validate the current results and determine the optimal contrast-agent concentration.
目的
本研究旨在确定超声造影剂（声诺维）在超声造影（CEUS）期间瘤内应用的适用性和最佳浓度。
方法
建立了一个模拟下颌升支解剖环境中现有病变的体外模型。瘤内应用后，在锥形束计算机断层扫描期间，将不同稀释度的声诺维与含碘放射造影剂（碘海醇300）的稀释液进行比较。
结论
在1/10和1/20的稀释度下，声诺维在区分病变与周围软组织方面提供了显著的造影效果。即使在1/50和1/100的稀释度下，碘海醇300的造影效果也略优。然而，低稀释度的声诺维CEUS似乎适用于体外瘤内应用。需要进一步的体内研究来验证当前结果并确定最佳造影剂浓度。
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