波斯湾吉兰队列研究（PGCS）人群中粪便免疫化学检测结果呈阳性和阴性的老年个体的结肠病变

Colon lesions in elderly individuals with positive and negative fecal immunochemical test results among PERSIAN Guilan cohort study (PGCS) population.

作者信息

Balou Heydar Ali, Joukar Farahnaz, Orang Goorabzarmakhi Mahdi, Shahdkar Milad, Hassanipour Soheil, Maroufizadeh Saman, Asgharnezhad Mehrnaz, Karimian Paridokht, Mansour-Ghanaei Fariborz

机构信息

Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.

Department of Biostatistics, School of Health, Guilan University of Medical Sciences, Rasht, Iran.

出版信息

Caspian J Intern Med. 2025 Dec 24;16(3):451-457. doi: 10.22088/cjim.16.3.451. eCollection 2025 Summer.

DOI:10.22088/cjim.16.3.451

PMID:40881612

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12329380/

Abstract

BACKGROUND

Early colorectal cancer (CRC) detection helps reduce the mortality rate. This study aimed to investigate colon lesions in individuals with positive and negative fecal immunochemical test (FIT) results among the (PERSIAN) Guilan cohort study (PGCS) population

METHODS

This cross-sectional study was conducted on 1158 participants over 50 who were volunteers for the FIT stool test at the Endoscopy Department of Razi Hospital, Rasht, Iran, from 2021 to 2022. The FIT test was screened for all participants, and for 172 individuals (86 individuals from each group with positive and negative FIT results), a colonoscopy was performed to investigate the colon lesions. Demographic/clinical characteristics, FIT results, colonoscopy findings, and the Bristol Stool Chart were completed. All data were analyzed using SPSS Version 16, considering a significant level<0.05

RESULTS

Out of 1,158 participants, 86 had positive FIT results, and 172 (52.3%) were females. The colonoscopy results showed that 34.3% of the patients had colon lesions. Individuals with positive FIT exhibited a significantly higher prevalence of colon lesions (p<0.001). No statistically significant differences were observed between positive and negative FIT results, demographic and clinical characteristics, and the location of lesions in individuals with colon lesions (p>0.05). Moreover, there was a significant difference in pathological findings and the presence of adenomatous polyps regarding the FIT results (p<0.001).

CONCLUSION

The effectiveness of FIT in the initial stages of screening for early lesion detection is considerable, especially for individuals with upper age.

摘要

背景

早期结直肠癌（CRC）检测有助于降低死亡率。本研究旨在调查（波斯）吉兰队列研究（PGCS）人群中粪便免疫化学检测（FIT）结果为阳性和阴性的个体的结肠病变情况。

方法

本横断面研究于2021年至2022年对伊朗拉什特市拉齐医院内镜科1158名50岁以上自愿参加FIT粪便检测的参与者进行。对所有参与者进行FIT检测，对172名个体（FIT结果为阳性和阴性的每组86名个体）进行结肠镜检查以调查结肠病变。完成人口统计学/临床特征、FIT结果、结肠镜检查结果和布里斯托大便分类法。所有数据均使用SPSS 16版进行分析，显著性水平<0.05。

结果

在1158名参与者中，86名FIT结果为阳性，172名（52.3%）为女性。结肠镜检查结果显示，34.3%的患者有结肠病变。FIT结果为阳性的个体结肠病变患病率显著更高（p<0.001）。FIT结果为阳性和阴性的个体、人口统计学和临床特征以及有结肠病变个体的病变部位之间未观察到统计学显著差异（p>0.05）。此外，FIT结果在病理结果和腺瘤性息肉的存在方面存在显著差异（p<0.001）。