Çulha Merve, Lira Fabio S, Rosa-Neto Jose C
Immunometabolism Lab, Institute of Biomedical Sciences and Faculty of Medicine from University of São Paulo, Graduate Program in Oncology, São Paulo, Brazil.
Exercise and Immunometabolism Research Group, Post-graduation Program in Movement Sciences, Department of Physical Education, Universidade Estadual Paulista (UNESP), São Paulo, Brazil.
Front Oncol. 2025 Aug 13;15:1595982. doi: 10.3389/fonc.2025.1595982. eCollection 2025.
Exercise decreases cancer risk, prevents recurrence and enhances treatment efficacy, however its exact mechanisms remain unclear. This review aims to (i) summarize the miRNAs released during aerobic exercise and explore the factors influencing their levels; (ii) discuss the miRNAs associated with cancer and exercise. Exercise alters circulated-miRNA levels. Some of them show benefits on tumor and anti-tumoral immune cells (miRNA-1, miRNA-133, miRNA-206, miRNA-208, miRNA-486, miRNA-499) and others exert adverse effects (miRNA-21, miRNA-221). Mechanisms of exercise effects on cancer are complex due to some exercise- induced miRNAs exert advantageous, others not, individual characteristics and exercise features influencing the miRNAs levels. Further studies are needed to elaborate the exercise features on immune response and tumor cell functions, including miRNA production.
运动可降低癌症风险、预防复发并提高治疗效果，但其确切机制尚不清楚。本综述旨在：（i）总结有氧运动过程中释放的微小RNA（miRNA），并探讨影响其水平的因素；（ii）讨论与癌症和运动相关的miRNA。运动可改变循环miRNA水平。其中一些对肿瘤和抗肿瘤免疫细胞有有益作用（miRNA-1、miRNA-133、miRNA-206、miRNA-208、miRNA-486、miRNA-499），而其他一些则产生不利影响（miRNA-21、miRNA-221）。由于一些运动诱导的miRNA具有优势，而另一些则不然，且个体特征和运动特征会影响miRNA水平，因此运动对癌症的影响机制很复杂。需要进一步研究来阐明运动对免疫反应和肿瘤细胞功能（包括miRNA产生）的特征。
Zotero 插件