新型冠状病毒肺炎（COVID-19）老年住院患者的离子钙水平与3个月死亡率之间的关联

Association between ionized calcium levels and 3-months mortality in geriatric patients hospitalized for COVID-19.

作者信息

Boudaille Audrey, Bourgeais Alexis, Corvaisier Mathieu, Brière Olivier, Gautier Jennifer, Annweiler Cédric

机构信息

UNIV ANGERS, Health Faculty, University of Angers, Angers, France; Department of Geriatric Medicine and Memory Clinic, Research Center on Autonomy and Longevity, University Hospital, Angers, France.

UNIV ANGERS, Health Faculty, University of Angers, Angers, France; Department of Geriatric Medicine and Memory Clinic, Research Center on Autonomy and Longevity, University Hospital, Angers, France; UNIV ANGERS, UPRES EA 4638, University of Angers, France.

出版信息

J Nutr Health Aging. 2025 Aug 28;29(9):100661. doi: 10.1016/j.jnha.2025.100661.

DOI:10.1016/j.jnha.2025.100661

PMID:40882292

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12409980/

Abstract

OBJECTIVES

The aim of this study was to determine an association between ionized calcium (CaI) levels and mortality 3 months after Covid-19 infection in geriatric population.

DESIGN

Observational retrospective cohort study.

SETTING AND PARTICIPANTS

One hundred and seventy-nine patients hospitalized in the geriatric acute care unit of Angers University Hospital were included. This specific unit specifically dedicated to COVID-19 patients was opened for 2 periods : from March 1, 2020 to June 30, 2020 and from October 1, 2020 to March 29, 2021. Covariates considered were: age, sex, Iso-Resources Groups (GIR) score ≤ 3, Parathyroid hormone (PTH), C-Reactive Protein (CRP), severe undernutrition defined as albumin < 30 g/L, history of cancer, history of cardiomyopathy, severe chronic renal failure (defined as clearance < 30 ml/min), Ordinal Scale for Clinical Improvement (OSCI) score, use of systemic corticosteroids and usual vitamin D supplementation. Direct potentiometry was also used as a covariate.

MEASUREMENTS

The time elapsed between the diagnosis of COVID-19 and death was studied by survival curves calculated using Cox model in each group defined by serum CaI concentration (>1.22 and ≤1.22 mmol/L).

RESULTS

In the Cox model, a significant association was found between CaI over 1.22 mmol/l and 3-months mortality, analyzed in an adjusted model (HR 2.40 [1.34-4.31], p = 0.003).

CONCLUSION

There is an association between CaI and 3 months mortality in geriatric patients hospitalized for COVID-19.

摘要

目的

本研究旨在确定老年人群新冠病毒感染后3个月时离子钙（CaI）水平与死亡率之间的关联。

设计

观察性回顾性队列研究。

设置与参与者

纳入了179名入住昂热大学医院老年急性护理病房的患者。这个专门收治新冠患者的特定病房开放了两个时间段：2020年3月1日至2020年6月30日以及2020年10月1日至2021年3月29日。考虑的协变量有：年龄、性别、等资源组（GIR）评分≤3、甲状旁腺激素（PTH）、C反应蛋白（CRP）、白蛋白<30 g/L定义的严重营养不良、癌症病史、心肌病病史、严重慢性肾衰竭（定义为肌酐清除率<30 ml/min）、临床改善序贯量表（OSCI）评分、全身使用皮质类固醇以及常规维生素D补充情况。直接电位测定法也用作协变量。