Nishiwaki H, Satake K, Umeyama K
Nihon Geka Gakkai Zasshi. 1985 Sep;86(9):1173-6.
The postprandial plasma secretin concentrations were investigated in patients with Billroth I, Billroth II, Roux-en Y and jejunal interposition following gastrectomy or modified Child's reconstruction after pancreatoduodenectomy. In patients with Billroth I anastomosis the postprandial plasma secretin response was not so high as that for normal volunteers, however it was much better compared with Billroth II anastomosis and Roux-en Y anastomosis after total gastrectomy. In an interposed jejunal anastomosis after total gastrectomy the plasma secretin increased at 20 minutes in postprandial state, even though there was not clear postprandial response of plasma secretin in patients with Roux-en Y anastomosis. Following the modified Child's method after pancreatoduodenectomy the postprandial plasma secretin response was similar to that of Billroth II anastomosis. Following acid load plasma secretin response was much higher than that of postprandial state in patients with Billroth-I, Billroth-II and Roux-Y anastomosis after gastrectomy. The results indicate that acid is important in stimulating secretin release and also the passage of food through the duodenum is important for the release of secretin.
对胃切除术后采用毕罗Ⅰ式、毕罗Ⅱ式、Roux-en Y式和空肠间置术，或胰十二指肠切除术后采用改良Child法重建的患者，研究其餐后血浆促胰液素浓度。在毕罗Ⅰ式吻合的患者中，餐后血浆促胰液素反应不如正常志愿者高，但与全胃切除术后的毕罗Ⅱ式吻合和Roux-en Y式吻合相比要好得多。在全胃切除术后的空肠间置吻合中，餐后状态下血浆促胰液素在20分钟时升高，尽管Roux-en Y式吻合的患者血浆促胰液素没有明显的餐后反应。胰十二指肠切除术后采用改良Child法，餐后血浆促胰液素反应与毕罗Ⅱ式吻合相似。胃切除术后采用毕罗Ⅰ式、毕罗Ⅱ式和Roux-Y式吻合的患者，酸负荷后血浆促胰液素反应比餐后状态高得多。结果表明，酸在刺激促胰液素释放方面很重要，食物通过十二指肠对促胰液素的释放也很重要。
