BinShabaib Munerah Saleh, Al-Wahibi Abdulrahman A
Department of Preventive Dental Sciences, College of Dentistry, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Department of Psychiatry, College of Medicine, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.
Sci Rep. 2025 Aug 29;15(1):31915. doi: 10.1038/s41598-025-85111-1.
The null hypothesis was that there is no difference in whole salivary cortisol levels (CL) and peri-implant health status among adults with and without a diagnosis of mental health disorders (MHD). The aim was to assess whole salivary CL and peri-implant health status among adults with and without MHD. The inclusion criteria were: (a) adults with at least one dental implant in function for at least one year; (b) adults with and without a diagnosis of MHD. Patients were divided into two-groups: (a) patients with depression (test-group); and (b) patients without MHD (control-group). Information on duration and treatment of depression and implant-related parameters were recorded. Periodontal parameters (plaque and gingival indices [PI and GI], probing depth (PD), clinical attachment loss [CAL] and marginal bone loss [MBL]) were measured. Peri-implant modified plaque and gingival indices (mPI and mGI), PD and crestal bone loss (CBL) were also recorded. Whole salivary cortisol levels were assessed in unstimulated whole saliva. Group comparisons were done and level of significance was set at P < 5%. Sixty-five individuals (33 and 32 in the test and control-groups, respectively) were included. Peri-implant mPI (P < 0.01), mGI (P < 0.01), PD (P < 0.01) and mesial (P < 0.01) and distal (P < 0.01) CBL were higher in the test than control group. Scores of full -mouth PI (P < 0.01), GI (P < 0.01), PD (P < 0.01), CAL (P < 0.01) and mesial (P < 0.01) and distal (P < 0.01) MBL were higher in the test than the control group. Unstimulated whole salivary flow rate was higher in the control than in the test group (P < 0.01). Whole salivary CL were higher in the test than in the control group (P < 0.01). There was a correlation between periodontal and peri-implant PD and whole salivary CL (P < 0.05) in the test group. Patients with MHD are more prone to peri-implant diseases compared to healthy individuals, with inadequate oral hygiene maintenance being the main contributing factor in the former group. Patients with MHD are more prone to periodontal and peri-implant diseases; and poor routine oral hygiene maintenance plays a critical role in this regard.
零假设为，被诊断患有和未患有精神健康障碍（MHD）的成年人的全唾液皮质醇水平（CL）和种植体周围健康状况无差异。目的是评估患有和未患有MHD的成年人的全唾液CL和种植体周围健康状况。纳入标准为：（a）至少有一颗功能正常的牙种植体且使用至少一年的成年人；（b）被诊断患有和未患有MHD的成年人。患者被分为两组：（a）抑郁症患者（试验组）；（b）未患有MHD的患者（对照组）。记录抑郁症的病程和治疗情况以及与种植体相关的参数。测量牙周参数（菌斑和牙龈指数[PI和GI]、探诊深度（PD）、临床附着丧失[CAL]和边缘骨丧失[MBL]）。还记录种植体周围改良菌斑和牙龈指数（mPI和mGI）、PD和嵴顶骨丧失（CBL）。在未刺激的全唾液中评估全唾液皮质醇水平。进行组间比较，显著性水平设定为P < 5%。纳入65名个体（试验组和对照组分别为33名和32名）。试验组的种植体周围mPI（P < 0.01）、mGI（P < 0.01）、PD（P < 0.01）以及近中（P < 0.01）和远中（P < 0.01）CBL均高于对照组。试验组的全口PI（P < 0.01）、GI（P < 0.01）、PD（P < 0.01）、CAL（P < 0.01）以及近中（P < 0.01）和远中（P < 0.01）MBL评分均高于对照组。对照组未刺激的全唾液流速高于试验组（P < 0.01）。试验组的全唾液CL高于对照组（P < 0.01）。试验组中牙周和种植体周围PD与全唾液CL之间存在相关性（P < 0.05）。与健康个体相比，患有MHD的患者更容易患种植体周围疾病，口腔卫生维护不足是前一组的主要促成因素。患有MHD的患者更容易患牙周和种植体周围疾病；在这方面，日常口腔卫生维护不佳起着关键作用。
