Kumakech Edward, Benyumiza Deo, Musinguzi Marvin, Inzama Wilfred, Doryn Ebong, Okello James, Kabiri Lydia, Ogwal-Okeng Jasper Watson
Department of Nursing, Faculty of Nursing and Midwifery, Lira University, P.O. Box 1035, Lira, Uganda.
Department of Midwifery, Faculty of Nursing and Midwifery, Lira University, P.O. Box 1035, Lira, Uganda.
AIDS Res Ther. 2025 Aug 29;22(1):84. doi: 10.1186/s12981-025-00777-x.
Abortion is a critical reproductive health issue among young women living with HIV (YWLHIV). Despite the widespread use of the antiretroviral therapy (ART) for women of reproductive age, its impact on abortion prevalence remains unclear. We set out to determine the prevalence of abortion among the YWLHIV receiving TLD-based ART regimen in northern Uganda and its association with the ART regimen and duration alongside other key socio-demographic, reproductive health, lifestyle and facility access- related factors.
A cross-sectional study of YWLHIV who reported at least one pregnancy in northern Uganda. Using an interviewer-administered questionnaire, participants were asked about their abortion history, ART regimen and duration, contraceptive use, parity, male partner's HIV status, and access to community-based family planning resources. Descriptive statistics for abortion prevalence, Chi-square test, Fisher's Exact test, bivariate and multivariate Poisson regression analyses for the associations between these variables and the occurrence of abortion were used. The 5% significance level and 95% confidence intervals were considered.
We analyzed data of 268 YWLHIV who reported conceiving at least one pregnancy. The abortion prevalence was 20.9% (95% Confidence Interval (CI) of 16.2% - 26.1%). No significant association was found between the abortion experience and ART regimens nor duration. The significant predictors for abortion included awareness of public health facilities that provide family planning services, parity, sero-concordant HIV-positive partnerships, and modern contraceptive use.
This study found a substantial abortion prevalence of 20.9% among the YWLHIV in northern Uganda. There was no significant association between the occurrence of abortion and ART regimens nor duration. Key predictors of abortion included awareness of public health facilities that provide family planning services, parity, use of contraceptive methods and the male partner's HIV positive status. To reduce abortion, creation of awareness of public health facilities that provide family planning services, contraceptive use, and couple-focused HIV testing and status disclosure are recommended.
堕胎是感染艾滋病毒的年轻女性（YWLHIV）中一个关键的生殖健康问题。尽管抗逆转录病毒疗法（ART）在育龄妇女中广泛使用，但其对堕胎率的影响仍不明确。我们旨在确定乌干达北部接受基于替诺福韦酯（TLD）的抗逆转录病毒治疗方案的YWLHIV中的堕胎率，以及其与抗逆转录病毒治疗方案、治疗时长以及其他关键的社会人口统计学、生殖健康、生活方式和获得医疗服务相关因素之间的关联。
对乌干达北部报告至少有一次怀孕经历的YWLHIV进行横断面研究。通过访谈员协助填写问卷，询问参与者的堕胎史、抗逆转录病毒治疗方案及治疗时长、避孕措施使用情况、生育次数、男性伴侣的艾滋病毒感染状况以及获得社区计划生育资源的情况。采用堕胎率的描述性统计、卡方检验、费舍尔精确检验、双变量和多变量泊松回归分析来研究这些变量与堕胎发生之间的关联。设定显著性水平为5%，置信区间为95%。
我们分析了268名报告至少有一次怀孕经历的YWLHIV的数据。堕胎率为20.9%（95%置信区间为16.2% - 26.1%）。未发现堕胎经历与抗逆转录病毒治疗方案及治疗时长之间存在显著关联。堕胎的显著预测因素包括知晓提供计划生育服务的公共卫生设施、生育次数、血清学一致的艾滋病毒阳性伴侣关系以及现代避孕措施的使用。
本研究发现乌干达北部的YWLHIV中堕胎率高达20.9%。堕胎的发生与抗逆转录病毒治疗方案及治疗时长之间没有显著关联。堕胎的关键预测因素包括知晓提供计划生育服务的公共卫生设施、生育次数、避孕方法的使用以及男性伴侣的艾滋病毒阳性状态。为减少堕胎，建议提高对提供计划生育服务的公共卫生设施的知晓度、推广避孕措施使用，并开展以夫妻为重点的艾滋病毒检测及感染状况披露。
