二正丙基乙酸酯对大鼠大脑皮层富含突触体部分中γ-氨基丁酸（GABA）结合的影响。
Effect of di-n-propylacetate on the 'binding of GABA to synaptosome-enriched fraction of rat cerebral cortex.
作者信息
Kulig B M, Gonzalez-Portal C, Somoza E, Defeudis F V
出版信息
Psychopharmacology (Berl). 1977 Aug 16;53(3):255-7. doi: 10.1007/BF00492360.
PMID:408853
Abstract
The effect of di-n-propylacetate (DPA) on the 'binding' of gamma-aminobutyric acid (GABA) to a synaptosome-enriched fraction of rat cerebral cortex has been examined using differential centrifugation and double-isotope liquid scintillation spectrometry. DPA at 10(-4) M caused a slight decrease in GABA binding. This effect could explain in part the in vivo anticonvulsant and behavioral effects of this drug when administered to animals in high systemic doses.
摘要
已使用差速离心法和双同位素液体闪烁光谱法研究了二正丙基乙酸酯（DPA）对γ-氨基丁酸（GABA）与大鼠大脑皮层富含突触体的部分“结合”的影响。10⁻⁴ M的DPA导致GABA结合略有下降。这种效应可以部分解释该药物在高全身剂量下给动物给药时的体内抗惊厥和行为效应。
Zotero 插件