Clarke M B, Tyrrell D A, Barrett J J
Nucl Med Commun. 1985 Oct;6(10):641-8. doi: 10.1097/00006231-198510000-00005.
99Tcm tin colloid, modified by the addition of various amounts of the surfactant Pluronic F68 was evaluated as a new liver imaging agent in normal adult male volunteers. The relative amounts taken up in the liver and spleen were measured by two quantitative methods with a view to establishing the most useful technique. The changes in biodistribution resulting from mechanical shaking during preparation of the colloids and in vitro ageing of the preparations were assessed. The pharmacokinetics of uptake into liver and spleen of the various formulations tested were independent of Pluronic F68 content. However, at low levels of Pluronic F68 the liver:spleen ratio decreased as the colloid preparation was aged before use. At high levels of Pluronic F68 there was increased background activity. An optimum formulation was identified combining low background activity with a stable pattern of biodistribution independent of preparation age.
通过添加不同量的表面活性剂普朗尼克F68对99锝锡胶体进行改性，在正常成年男性志愿者中作为一种新型肝脏显像剂进行评估。采用两种定量方法测量肝脏和脾脏的相对摄取量，以确定最有用的技术。评估了胶体在制备过程中的机械振荡以及制剂的体外老化对生物分布的影响。所测试的各种制剂在肝脏和脾脏中的摄取药代动力学与普朗尼克F68含量无关。然而，在低水平的普朗尼克F68时，在使用前胶体制剂老化时，肝脾比会降低。在高水平的普朗尼克F68时，本底活性增加。确定了一种最佳制剂，其具有低本底活性和与制剂年龄无关的稳定生物分布模式。
