Sundram F X, Edmondson R P, Ang E S, Goh A S, Toh H J
Nucl Med Commun. 1986 Dec;7(12):897-906. doi: 10.1097/00006231-198612000-00008.
Technetium-99m-(tin) colloid uptake in renal transplants was quantified to evaluate rejection. A dynamic acquisition following i.v. injection of 110 MBq of this radiopharmaceutical enabled quantification of 15 to 20 min transplant uptake (PU), in terms of percentage of an injected dose after allowing for attenuation in the patient. An uptake ratio (UR) i.e. the ratio of 15 to 20 min uptake over the 0 to 5 min uptake was also derived. Normal values were obtained in 20 stable functioning transplants (normal PU less than or equal to 1%, normal UR less than or equal to 0.7). In 66 patients, PU and UR were compared with clinical, biochemical, histological and radiological, evidence of rejection. A sensitivity of 70% and specificity of 85% was obtained for this 99Tcm-(tin) colloid study in the diagnosis of renal transplant rejection.
对肾移植中锝-99m（锡）胶体摄取进行定量分析以评估排斥反应。静脉注射110 MBq这种放射性药物后进行动态采集，在考虑患者体内衰减因素后，能够以注射剂量的百分比形式对移植肾15至20分钟的摄取量（PU）进行定量分析。还得出了摄取率（UR），即15至20分钟摄取量与0至5分钟摄取量的比值。在20例功能稳定的移植肾中获得了正常值（正常PU小于或等于1%，正常UR小于或等于0.7）。在66例患者中，将PU和UR与排斥反应的临床、生化、组织学和放射学证据进行了比较。这项锝-99m（锡）胶体研究在诊断肾移植排斥反应中的敏感性为70%，特异性为85%。
