通过放射免疫分析法测定兔和犬脑脊液及血浆中的丙磺舒。
Probenecid in CSF and plasma of rabbits and dogs measured by radioimmunoassay.
作者信息
Shei W L, Mu J Y, Cunningham R F, Israili Z H, Dayton P G
出版信息
Psychopharmacology (Berl). 1977 Aug 16;53(3):315-8. doi: 10.1007/BF00492371.
PMID:408862
Abstract
Probenecid (P) in CSF of rabbits and dogs was investigated using a new radioimmunoassay technique. In rabbits, under steady-state conditions, CSF/free plasma concentration ratios of P were found to be similar to those reported in man. The ratios were concentration dependent and less than 0.5 suggesting an inhibition of transport of the drug in CNS. Under nonsteady-state conditions, no clear evidence of a transport system was found in dogs.
摘要
采用一种新的放射免疫分析技术对兔和犬脑脊液中的丙磺舒（P）进行了研究。在兔中，在稳态条件下，发现P的脑脊液/游离血浆浓度比与人报道的相似。这些比值与浓度有关，且小于0.5，提示该药物在中枢神经系统中的转运受到抑制。在非稳态条件下，未在犬中发现明确的转运系统证据。
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