Rakes S M, Yeatts R P, Campbell R J
Ophthalmology. 1985 Dec;92(12):1749-53. doi: 10.1016/s0161-6420(85)34102-7.
Esthesioneuroblastoma, a tumor that arises from the olfactory sensory epithelium, often manifests with ocular and orbital signs and symptoms. A review of 38 cases of esthesioneuroblastoma at the Mayo Clinic revealed that ophthalmic signs or symptoms occurred in 28. Twenty patients had ophthalmic signs or symptoms at the time of presentation, and five of these had ocular symptoms as the primary complaint. Five patients presented to an ophthalmologist, but a nasal or paranasal sinus tumor was not suspected. Periorbital pain and excessive tearing were the most commonly reported symptoms. The most common ophthalmic sign was eyelid edema followed by proptosis, globe injection, and ptosis. Recognition of the signs and symptoms of neoplasms of the nose and paranasal sinuses and consideration of esthesioneuroblastoma in the differential diagnosis by clinicians and pathologists allow for prompt management of this tumor.
嗅神经母细胞瘤是一种起源于嗅觉感觉上皮的肿瘤，常表现出眼部和眼眶的体征及症状。对梅奥诊所38例嗅神经母细胞瘤病例的回顾显示，28例出现了眼科体征或症状。20例患者在就诊时出现眼科体征或症状，其中5例以眼部症状为主诉。5例患者就诊于眼科医生，但当时未怀疑有鼻腔或鼻窦肿瘤。眶周疼痛和流泪过多是最常报告的症状。最常见的眼科体征是眼睑水肿，其次是眼球突出、眼球充血和上睑下垂。临床医生和病理学家认识到鼻和鼻窦肿瘤的体征及症状，并在鉴别诊断中考虑嗅神经母细胞瘤，有助于对该肿瘤进行及时治疗。
