Aisyah Rahmawati, Vatanapahu Ruj, Mihara Moe, Tagawa Takashi, Kanazawa Mai, Kuwahara Hiroshige, Chen Siyi, Bono Hidemasa, Kumrungsee Thanutchaporn, Yanaka Noriyuki
Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.
Research Center, Maruzen Pharmaceuticals, Co., Ltd, Onomichi, Japan.
J Food Sci. 2025 Sep;90(9):e70524. doi: 10.1111/1750-3841.70524.
Although Peucedanum japonicum Thunb (PJT) has been used in traditional medicine, PJT root is considered to be agricultural waste, and its benefits have not been explored to date. This study examined the effect of PJT root extract in C57BL/6J mice fed a high-fat diet (HFD) for 10 weeks and determined the underlying molecular mechanisms based on gene expression analyses. PJT supplementation (1% w/w) decreased body weight, white adipose tissue (WAT) mass, and hepatic triglyceride levels and downregulated inflammatory gene expression in the WAT and liver of HFD-fed mice. Notably, dramatic increases in Cyp2b and Ces2 mRNA levels, which are reportedly involved in lipid metabolism, were observed in the livers of PJT-supplemented, HFD-fed mice. Furthermore, short-term PJT supplementation in HFD-fed mice and PJT treatment in primary cultured hepatocytes suggested that PJT root extract modulates hepatic Cyp2b and Ces2 mRNA expression in a direct manner. Thus, these findings demonstrate the potential of PJT root extract as a functional food for obesity and fatty liver disease.
虽然明党参已被用于传统医学，但明党参根被认为是农业废弃物，其益处迄今尚未得到探索。本研究检测了明党参根提取物对喂食高脂饮食（HFD）10周的C57BL/6J小鼠的影响，并基于基因表达分析确定了潜在的分子机制。补充明党参（1% w/w）可降低体重、白色脂肪组织（WAT）质量和肝脏甘油三酯水平，并下调HFD喂养小鼠WAT和肝脏中的炎症基因表达。值得注意的是，在补充明党参的HFD喂养小鼠的肝脏中，观察到据报道参与脂质代谢的Cyp2b和Ces2 mRNA水平显著增加。此外，在HFD喂养小鼠中短期补充明党参以及在原代培养肝细胞中进行明党参处理表明，明党参根提取物以直接方式调节肝脏Cyp2b和Ces2 mRNA表达。因此，这些发现证明了明党参根提取物作为肥胖和脂肪肝疾病功能性食品的潜力。
