Beck F, Dörge A, Rick R, Thurau K
Pflugers Arch. 1985;405 Suppl 1:S28-32. doi: 10.1007/BF00581776.
Element concentrations were determined in various extra- and intracellular compartments of the rat renal papilla in antidiuresis and after furosemide-induced diuresis using electron microprobe analysis to elucidate further how the cells adapt osmotically to different osmolalities. In antidiuresis and diuresis the sum of intracellular cations (sodium and potassium), accompanying anions and urea was insufficient in both cases to provide cell osmolalities similar to those in extracellular compartments. This finding provides further evidence that the papillary cells achieve osmoadaptation to widely differing extracellular electrolyte concentrations mainly by varying the cellular concentrations of osmotically-active substances other than urea and electrolytes.
利用电子微探针分析技术，测定了大鼠肾乳头在抗利尿状态下以及速尿诱导利尿后，各种细胞外和细胞内区室中的元素浓度，以进一步阐明细胞如何在渗透压方面适应不同的渗透压。在抗利尿和利尿状态下，细胞内阳离子（钠和钾）、伴随的阴离子和尿素的总和在两种情况下都不足以使细胞渗透压与细胞外区室的渗透压相似。这一发现进一步证明，乳头细胞主要通过改变除尿素和电解质之外的渗透活性物质的细胞浓度，来实现对广泛不同的细胞外电解质浓度的渗透适应。
