Lee Eun-Ji, Jo Narae, Heo Tae-Young, Young-Youl Kim, Kwon Eunjin, Kang Min Gu, Jhong Jae-Hwan
Department of Information Statistics, 1, Chungdae-ro, Seowon-gu, Cheongju-si, Chungcheongbuk-do, 28644, Republic of Korea.
Division of Allergy and Chronic Respiratory Diseases, 187, Osongsaengmyeong2(i)-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-do, 28159, Republic of Korea.
Sci Rep. 2025 Sep 1;15(1):32138. doi: 10.1038/s41598-025-17352-z.
This study investigates the relationship between air pollution and lung function in the South Korean adult population using Bayesian Kernel Machine Regression (BKMR). By integrating 2017 Korea National Health and Nutrition Examination Survey (KNHANES) data with air pollution data, the study examines the individual and joint effects of key air pollutants-[Formula: see text], [Formula: see text], [Formula: see text], [Formula: see text], [Formula: see text], and CO-on lung function indicators, including COPD (binary) and [Formula: see text]FVC (continuous). The findings reveal that [Formula: see text] and [Formula: see text] have negative effects on lung function, both individually and interactively. As the concentrations of these pollutants increase, the probability of developing COPD and the decline in [Formula: see text]FVC become more pronounced. This study highlights the compounded risks posed by pollutant mixtures, providing critical insights for public health interventions and air quality policy improvements in South Korea. Future research directions include addressing time-lagged effects and regional variations to enhance the understanding of these relationships.
本研究使用贝叶斯核机器回归（BKMR）调查了韩国成年人群中空气污染与肺功能之间的关系。通过将2017年韩国国家健康与营养检查调查（KNHANES）数据与空气污染数据相结合，该研究考察了主要空气污染物——[公式：见原文]、[公式：见原文]、[公式：见原文]、[公式：见原文]、[公式：见原文]和一氧化碳——对肺功能指标的个体和联合影响，这些指标包括慢性阻塞性肺疾病（二元变量）和[公式：见原文]用力肺活量（连续变量）。研究结果显示，[公式：见原文]和[公式：见原文]对肺功能均有负面影响，无论是单独影响还是交互影响。随着这些污染物浓度的增加，患慢性阻塞性肺疾病的概率以及[公式：见原文]用力肺活量的下降变得更加明显。本研究强调了污染物混合物带来的复合风险，为韩国的公共卫生干预措施和空气质量政策改进提供了关键见解。未来的研究方向包括解决时间滞后效应和区域差异问题，以加深对这些关系的理解。
