Deng Yuhang, Xie Fenghao, Zhao Ziren, Wu Wenqing, Wang Di, Guna Yongjie, Zhang Qitong, Li Quan, Jiang Haoqin, Guan Ming
Department of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Hangzhou Medical College, 8 Yikang Street, Lin'an District, Hangzhou City, Zhejiang Province, China.
Sci Rep. 2025 Sep 2;15(1):32261. doi: 10.1038/s41598-025-17545-6.
We investigated inconsistencies between results for cystatin C (Cys C) and creatinine (Crea) in patients undergoing health check-ups. Data from 36,836 individuals who underwent health checkups at Huashan Hospital over the previous 3 years were analyzed. We extracted laboratory results of 10 biomarkers and information on sex and age. After applying detailed screening criteria, 14,968 participants were included in this study. We evaluated the consistency of the current reference intervals (RIs) for Cys C and Crea in assessing renal function across sex and age groups. The results showed that the current RIs led to inconsistent result interpretations when applied to different age and sex groups. Older individuals and men were more likely to have Cys C levels above the RIs whereas younger individuals were more likely to exceed the RIs for Crea. Age- and sex-dependency was observed for both biomarkers. We therefore developed new age- and sex-partitioned RIs for these markers. The updated RIs greatly improved the consistency of Cys C and Crea result interpretation across age and sex groups. Our findings indicated that Cys C and Crea are both dependent on age and sex, and using age- and sex-partitioned RIs improves interpretation consistency across different age and sex groups.
The online version contains supplementary material available at 10.1038/s41598-025-17545-6.
我们调查了健康体检患者中胱抑素C（Cys C）和肌酐（Crea）检测结果之间的不一致性。分析了过去3年在华山医院进行健康体检的36836人的数据。我们提取了10种生物标志物的实验室检测结果以及性别和年龄信息。在应用详细的筛选标准后，本研究纳入了14968名参与者。我们评估了当前Cys C和Crea的参考区间（RIs）在评估不同性别和年龄组肾功能时的一致性。结果表明，当应用于不同年龄和性别组时，当前的参考区间会导致结果解释不一致。老年人和男性的Cys C水平更有可能高于参考区间，而年轻人的Crea水平更有可能超过参考区间。两种生物标志物均观察到年龄和性别依赖性。因此，我们针对这些标志物制定了新的按年龄和性别划分的参考区间。更新后的参考区间大大提高了Cys C和Crea结果在不同年龄和性别组解释的一致性。我们的研究结果表明，Cys C和Crea均依赖于年龄和性别，使用按年龄和性别划分的参考区间可提高不同年龄和性别组解释的一致性。
在线版本包含可在10.1038/s41598-025-17545-6获取的补充材料。
